ID   MUTL_ANAD2              Reviewed;         607 AA.
AC   B8J9F5;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=A2cp1_2223;
OS   Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=455488;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-1 / ATCC BAA-258;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA   Beliaev A.S., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-1.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001359; ACL65561.1; -; Genomic_DNA.
DR   RefSeq; WP_012633402.1; NC_011891.1.
DR   AlphaFoldDB; B8J9F5; -.
DR   SMR; B8J9F5; -.
DR   EnsemblBacteria; ACL65561; ACL65561; A2cp1_2223.
DR   KEGG; acp:A2cp1_2223; -.
DR   HOGENOM; CLU_004131_4_2_7; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000007089; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..607
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192152"
SQ   SEQUENCE   607 AA;  63793 MW;  9F8B8D64DC3F402A CRC64;
     MPRIHVLPPG LVNQIAAGEV VERPASIVKE LVENALDAGA TSVGVDVEEG GLALVRVADD
     GSGMDRDDAL LALERHATSK LRDAEGLAAI GTMGFRGEAV PAIASVSRFR LDTSAGEDGA
     GTRVEIEGGV LGEVAPVARP RGTTVEVRDL FFNTPARRKF MRAASTEAGH VSEAVIRLAL
     ARPDVGFTLR SAGRLVLGAR AGGGLADRAG QALGREAHRH LLPVDARRGE VRVHGLICSP
     DHSEATGRAL YLFVNGRYVR DRAAAHAVLR AFAGTLPPGR HPAGVLFVEL PLHRVDVNVH
     PQKLEVRFAE GREVFDALFH TVAGALRTAP WLRARPQPGD GVPAGNGGGP APVPVAGEEA
     AEVLAWARAA RPPEGSGATL VQPAPGAWAT GRLAFPVAPA PGAGPEAGPR PEGYFAALRY
     VGQHARTYLL CEAPGGTLVV IDQHASHERM LFHRLREAFR ARRIPVQPFL LPQVVTLPPA
     AARALEAGLA ELGRLGFDAE PFGGEAFAVK GAPAALAGVD LTALLTDLGS QLAEVERGSA
     VDDAFHDLLA TMACHAAVRA NQDVSPEEAR ALLDGLDAID FKARCPHGRP VVFELSLADL
     ERRVGRR