ID   MUTL_ANADE              Reviewed;         608 AA.
AC   Q2IIL0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Adeh_1715;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N.,
RA   Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R.,
RA   Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000251; ABC81488.1; -; Genomic_DNA.
DR   RefSeq; WP_011420771.1; NC_007760.1.
DR   AlphaFoldDB; Q2IIL0; -.
DR   SMR; Q2IIL0; -.
DR   STRING; 290397.Adeh_1715; -.
DR   EnsemblBacteria; ABC81488; ABC81488; Adeh_1715.
DR   KEGG; ade:Adeh_1715; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_7; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..608
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076686"
SQ   SEQUENCE   608 AA;  63857 MW;  9A22B0641EBFF9C7 CRC64;
     MPRIHVLPPG LVNQIAAGEV VERPASIVKE LVENALDAGA TAIGVDVEEG GLALVRVADD
     GSGMDRDDAL LALERHATSK LRDAEGLAAI GTMGFRGEAV PAIASVSRFR LDTSPGEDGA
     GTRVEIEGGV LGEVAPVARP RGTTVEVRDL FFNTPARRKF MRAASTEAGH VSEAVIRLAL
     ARPDVGFTLR SGGRLVLGAR AGGGLADRAG QALGREAHRH LLPVDARRGE VRVHGLICSP
     DHSEATGRAL YLFVNGRYVR DRAAAHAVLR AFAGTLPPGR HPAGVLFVEL PLDRVDVNVH
     PQKLEVRFAE GREVFDALFH TVAGALRTAP WLRARPQAAP AGEGPPAGGE AVAVPLAGED
     AAAVLAWARA ARPPEGSGAT LVQPAPGAWA TGRLAFPIAP APDAGPEAAP RPEGYFAGLR
     YVGQHARTYL LCEAPGGTLV VIDQHASHER MLFHRLKEAF RARRIPVQPY LLPQVVTLPP
     AAARALEAGL AELGRLGFDA EPFGGDAFAV KGAPAALAGV DLTALLTDLG SQLADVERGS
     AVDDAFHDLL ATMACHAAVR ANQDVSPEEA RALLDGLDAI DFKARCPHGR PVVFELSLAD
     LERRVGRR