ID   MUTL_ANASK              Reviewed;         607 AA.
AC   B4UCW3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=AnaeK_2133;
OS   Anaeromyxobacter sp. (strain K).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter;
OC   unclassified Anaeromyxobacter.
OX   NCBI_TaxID=447217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikiva G.,
RA   Beliaev A.;
RT   "Complete sequence of Anaeromyxobacter sp. K.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001131; ACG73360.1; -; Genomic_DNA.
DR   RefSeq; WP_012526161.1; NC_011145.1.
DR   AlphaFoldDB; B4UCW3; -.
DR   SMR; B4UCW3; -.
DR   EnsemblBacteria; ACG73360; ACG73360; AnaeK_2133.
DR   KEGG; ank:AnaeK_2133; -.
DR   HOGENOM; CLU_004131_4_2_7; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001871; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..607
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096626"
SQ   SEQUENCE   607 AA;  63822 MW;  8491CB5D72A66F0E CRC64;
     MPRIHVLPPG LVNQIAAGEV VERPASIVKE LVENALDAGA TSVGVDVEEG GLALVRVADD
     GSGMDRDDAL LALERHATSK LRDAEGLAAI GTMGFRGEAV PAIASVSRFR LDTSAGEDGA
     GTRVEIEGGV LGEVAPVARP RGTTVEVRDL FFNTPARRKF MRAASTEAGH VSEAVIRLAL
     ARPDVGFTLR SGGRLVLGAR AGGGLADRAG QALGREAHRH LLPVDARRGE VRVHGLICSP
     DHSEATGRAL YLFVNGRYVR DRAAAHAVLR AFAGTLPPGR HPAGVLFVEL PLHRVDVNVH
     PQKLEVRFAE GREVFDALFH TVAGALRTAP WLRARPQPGD GVPVGDGGGP APVPVAGEEA
     AEVLAWARAA RPPEGSGATL VQPAPGAWAT GRLAFPVVPA PGAGPEAGPR PEGYFAGLRY
     VGQHARTYLL CEAPGGTLVV IDQHASHERM LFHRLREAFR ARRIPVQPFL LPQVVTLPPA
     AARALEAGLA ELGRLGFDAE PFGGEAFAVK GAPAALAGVD LTALLTDLGS QLAEVERGSA
     VDDAFHDLLA TMACHAAVRA NQDVSPEEAR ALLDGLDAID FKARCPHGRP VVFELSLADL
     ERRVGRR