ID   MUTL_ANOFW              Reviewed;         608 AA.
AC   B7GIA3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Aflv_1519;
OS   Anoxybacillus flavithermus (strain DSM 21510 / WK1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Anoxybacillus.
OX   NCBI_TaxID=491915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21510 / WK1;
RX   PubMed=19014707; DOI=10.1186/gb-2008-9-11-r161;
RA   Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A.,
RA   Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V.,
RA   Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.;
RT   "Encapsulated in silica: genome, proteome and physiology of the
RT   thermophilic bacterium Anoxybacillus flavithermus WK1.";
RL   Genome Biol. 9:R161.1-R161.16(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000922; ACJ33885.1; -; Genomic_DNA.
DR   RefSeq; WP_012575114.1; NC_011567.1.
DR   AlphaFoldDB; B7GIA3; -.
DR   SMR; B7GIA3; -.
DR   STRING; 491915.Aflv_1519; -.
DR   PRIDE; B7GIA3; -.
DR   EnsemblBacteria; ACJ33885; ACJ33885; Aflv_1519.
DR   KEGG; afl:Aflv_1519; -.
DR   PATRIC; fig|491915.6.peg.1564; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000742; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..608
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192153"
SQ   SEQUENCE   608 AA;  69260 MW;  181D0C2CCEE927E8 CRC64;
     MGKIRKLDDA LANKIAAGEV VERPASVVKE LVENAIDAHS TIIEVELEEA GLAKIRVVDN
     GDGFEEEDCF LAFERHATSK IKDEADLFRI RTLGFRGEAL PSIASVSHLE LKTSTGEGPG
     TWLVLKGGEL VQHGRTSSRK GTDITVSHLF FNTPARLKYM KTIHTELGHV VDVINRLALA
     HPHISFRLTH NGKQLFYTNG NGDVRQVLAA IYGLDVAKKM IAIHAETLDF TIDGYVALPE
     VTRASRNYMT TIVNGRYIKN YSLYKAIEEG YHTLLPIGRH PITFLNIMMD PLLIDVNVHP
     AKLEVRFSKE TELNELVQQT IRQSFQKKTL IPEVTAPRVE KTKAEQQTFS FEHIVKESNT
     MSPRVTEIHR DQEKKTEERI VLEKSDEHVR DQDVTLLDVE SVVPSEHVTG EMDQERIPPL
     YPIGQMHGTY ILAQNENGLY IIDQHAAQER IKYEYFREKL ATVTNELQPL LIPLTLTYSS
     SEYLLIESYR DQLAACGVFL EPFGHNSFIV RSHPQWFPKG EEVAIIEEMI KQVLEMKKVD
     MKQLREKAAI MMSCKQSIKA NQFLRNDEIF ALLESLRKTS DPFTCPHGRP IIIHFSTYEL
     EKMFKRVM