MUTL_AQUAE
ID MUTL_AQUAE Reviewed; 425 AA.
AC O67518;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=DNA mismatch repair protein MutL;
GN Name=mutL; OrderedLocusNames=aq_1578;
OS Aquifex aeolicus (strain VF5).
OC Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX NCBI_TaxID=224324;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL Nature 392:353-358(1998).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000305}.
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DR EMBL; AE000657; AAC07483.1; -; Genomic_DNA.
DR PIR; D70436; D70436.
DR RefSeq; NP_214083.1; NC_000918.1.
DR RefSeq; WP_010881021.1; NC_000918.1.
DR PDB; 5B42; X-ray; 1.35 A; A=325-425.
DR PDB; 5X9Y; X-ray; 3.44 A; A/B/C=9-315.
DR PDB; 5Z41; X-ray; 1.70 A; A=324-425.
DR PDB; 5Z42; X-ray; 1.30 A; A=324-425.
DR PDB; 6LZI; X-ray; 1.69 A; A=9-315.
DR PDB; 6LZJ; X-ray; 1.73 A; A=9-315.
DR PDB; 6LZK; X-ray; 3.16 A; A/B/C=9-315.
DR PDBsum; 5B42; -.
DR PDBsum; 5X9Y; -.
DR PDBsum; 5Z41; -.
DR PDBsum; 5Z42; -.
DR PDBsum; 6LZI; -.
DR PDBsum; 6LZJ; -.
DR PDBsum; 6LZK; -.
DR AlphaFoldDB; O67518; -.
DR SMR; O67518; -.
DR STRING; 224324.aq_1578; -.
DR EnsemblBacteria; AAC07483; AAC07483; aq_1578.
DR KEGG; aae:aq_1578; -.
DR PATRIC; fig|224324.8.peg.1217; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_0; -.
DR InParanoid; O67518; -.
DR OMA; YFFDQHL; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000000798; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 3.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..425
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_0000177924"
FT HELIX 23..36
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 40..47
FT /evidence="ECO:0007829|PDB:6LZI"
FT TURN 48..51
FT /evidence="ECO:0007829|PDB:6LZJ"
FT STRAND 53..58
FT /evidence="ECO:0007829|PDB:6LZI"
FT HELIX 65..68
FT /evidence="ECO:0007829|PDB:6LZI"
FT HELIX 69..71
FT /evidence="ECO:0007829|PDB:6LZI"
FT HELIX 98..103
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 106..113
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 118..126
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 129..136
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 140..148
FT /evidence="ECO:0007829|PDB:6LZI"
FT TURN 149..152
FT /evidence="ECO:0007829|PDB:6LZI"
FT HELIX 154..158
FT /evidence="ECO:0007829|PDB:6LZI"
FT HELIX 163..180
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 184..190
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 193..198
FT /evidence="ECO:0007829|PDB:6LZI"
FT HELIX 203..211
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 216..220
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 226..232
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 239..244
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 247..249
FT /evidence="ECO:0007829|PDB:6LZI"
FT HELIX 252..261
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 267..273
FT /evidence="ECO:0007829|PDB:6LZI"
FT HELIX 299..305
FT /evidence="ECO:0007829|PDB:6LZI"
FT STRAND 329..334
FT /evidence="ECO:0007829|PDB:5Z42"
FT TURN 335..337
FT /evidence="ECO:0007829|PDB:5Z42"
FT STRAND 338..342
FT /evidence="ECO:0007829|PDB:5Z42"
FT STRAND 344..351
FT /evidence="ECO:0007829|PDB:5Z42"
FT HELIX 352..364
FT /evidence="ECO:0007829|PDB:5Z42"
FT HELIX 367..373
FT /evidence="ECO:0007829|PDB:5Z42"
FT HELIX 383..395
FT /evidence="ECO:0007829|PDB:5Z42"
FT STRAND 399..401
FT /evidence="ECO:0007829|PDB:5Z42"
FT STRAND 407..413
FT /evidence="ECO:0007829|PDB:5Z42"
FT HELIX 414..420
FT /evidence="ECO:0007829|PDB:5Z42"
SQ SEQUENCE 425 AA; 49594 MW; 81BB98DF624C2A7D CRC64;
MFVKLLPPEV RKVIAAGEVI ESPVDVVKEL VENSLDAKAT KVEVEIVKGG KRLIRVKDNG
TGIHPEDVEK VVLQGATSKI ETEKDLMNIS TYGFRGEALY SISSVSKFKL RSRFFQEKEG
KEIEVEAGNI LGTRRVGMPV GTEVEVRDLF FNLPVRRKFL KKEDTERRKV LELIKEYALT
NPEVEFTLFS EGRETLKLKK SSLKERVEEV FQTKTEELYA EREGITLRAF VSRNQRQGKY
YVFINKRPIQ NKNLKEFLRK VFGYKTLVVL YAELPPFMVD FNVHPKKKEV NILKERKFLE
LVRELAGKEK PIVDIPLSQP VKTYKPTYEI LGQMDETFIL VKDSEYLYFV DQHLLEERIN
YEKLKDENLA CRISVKAGQK LSEEKIRELI KTWRNLENPH VCPHGRPIYY KIPLREIYEK
VGRNY
