ID   MUTL_AQUPY              Reviewed;         426 AA.
AC   P70754;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL;
OS   Aquifex pyrophilus.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=2714;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Wetmur J.G., Rosenfeld A., Wong D.M.;
RT   "Expression and characterization of MutL proteins from thermophilic
RT   eubacteria.";
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; U71052; AAB09595.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70754; -.
DR   SMR; P70754; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 3.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF118116; SSF118116; 2.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..426
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177925"
SQ   SEQUENCE   426 AA;  49792 MW;  D819943EE45E7DC4 CRC64;
     MFVKILPPEV RRKIAAGEVI DAPVDVVKEL IENSLDAKAT RIEIEVVKGG KRLIRVKDNG
     IGIHPEDIEK VVLSGATSKI EKETDLLNVE TYGFRGEALY SISSVSKFRL RSRFYQEKEG
     REIEVEGGTL KSVRRVGMEV GTEVEVYDLF FNLPARKKFL RKEDTERRKI TELVKEYAIT
     NPQVDFHLFS EGKETLNLKK KDLKGRIEEI FESIFEEESS EREGIKVRAF ISRNQKRGKY
     YLFVNSRPVY NKNLKEYLKK TFGYKTIVVL FIDIPPFLVD FNVHPKKKEV KFLKERKIYE
     LIRELSSRKH TILEIPTLNQ KTESYKPTYE VIGQLNETFI LVSDGNFLYF IDQHLLDERI
     NYEKNGNEEL ACRISVKAGE KLTNEKIKEL IKEWKKLENP HVCPHGRPIY YKLPLKEVYE
     KLGRSF