MUTL_BACAA
ID MUTL_BACAA Reviewed; 626 AA.
AC C3P5H4;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BAA_3929;
OS Bacillus anthracis (strain A0248).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=592021;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A0248;
RA Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D.,
RA Brettin T.;
RT "Genome sequence of Bacillus anthracis A0248.";
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP001598; ACQ50577.1; -; Genomic_DNA.
DR RefSeq; WP_000516478.1; NC_012659.1.
DR AlphaFoldDB; C3P5H4; -.
DR SMR; C3P5H4; -.
DR GeneID; 45023597; -.
DR KEGG; bai:BAA_3929; -.
DR HOGENOM; CLU_004131_4_1_9; -.
DR OMA; AHERIMY; -.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..626
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000192154"
FT REGION 377..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 71456 MW; 1850CC3A345AB0FC CRC64;
MGKIRKLDDQ LSNLIAAGEV VERPASVVKE LVENSIDANS TSIEIHLEEA GLSKIRIIDN
GDGIAEEDCI VAFERHATSK IKDENDLFRI RTLGFRGEAL PSIASVSELE LITSTGDAPG
THLIIKGGDI IKQEKTASRK GTDITVQNLF FNTPARLKYM KTIHTELGNI TDIVYRIAMS
HPEVSLKLFH NEKKLLHTSG NGDVRQVLAS IYSIQVAKKL VPIEAESLDF TIKGYVTLPE
VTRASRNYMS TIVNGRYVRN FVLMKAIQQG YHTLLPVGRY PIGFLSIEMD PMLVDVNVHP
AKLEVRFSKE QELLKLIEET LQAAFKKIQL IPDAGVTTKK KEKDESVQEQ FQFEHAKPKE
PSMPEIVLPT GMDEKQEEPQ AVKQPTQLWQ PSTKPIIEEP IQEEKSWDSN EEGFELEELE
EVREIKEIEM NGNDLPPLYP IGQMHGTYIF AQNDKGLYMI DQHAAQERIN YEYFRDKVGR
VAQEVQELLV PYRIDLSLTE FLRVEEQLEE LKKVGLFLEQ FGHQSFIVRS HPTWFPKGQE
TEIIDEMMEQ VVKLKKVDIK KLREEAAIMM SCKASIKANQ YLTNDQIFAL LEELRTTTNP
YTCPHGRPIL VHHSTYELEK MFKRVM