ID   MUTL_BACAN              Reviewed;         626 AA.
AC   Q81WR4; Q6HUW8; Q6KP44;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=BA_3904, GBAA_3904, BAS3617;
OS   Bacillus anthracis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1392;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames / isolate Porton;
RX   PubMed=12721629; DOI=10.1038/nature01586;
RA   Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA   Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA   Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA   Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA   DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA   Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA   Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA   Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA   White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA   Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT   "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT   related bacteria.";
RL   Nature 423:81-86(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sterne;
RA   Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA   Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA   Richardson P., Rubin E., Tice H.;
RT   "Complete genome sequence of Bacillus anthracis Sterne.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ames ancestor;
RX   PubMed=18952800; DOI=10.1128/jb.01347-08;
RA   Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA   Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT   "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL   J. Bacteriol. 191:445-446(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE016879; AAP27637.1; -; Genomic_DNA.
DR   EMBL; AE017334; AAT33017.1; -; Genomic_DNA.
DR   EMBL; AE017225; AAT55921.1; -; Genomic_DNA.
DR   RefSeq; NP_846151.1; NC_003997.3.
DR   RefSeq; WP_000516478.1; NZ_WXXJ01000001.1.
DR   RefSeq; YP_029870.1; NC_005945.1.
DR   AlphaFoldDB; Q81WR4; -.
DR   SMR; Q81WR4; -.
DR   IntAct; Q81WR4; 8.
DR   STRING; 260799.BAS3617; -.
DR   DNASU; 1085120; -.
DR   EnsemblBacteria; AAP27637; AAP27637; BA_3904.
DR   EnsemblBacteria; AAT33017; AAT33017; GBAA_3904.
DR   GeneID; 45023597; -.
DR   KEGG; ban:BA_3904; -.
DR   KEGG; bar:GBAA_3904; -.
DR   KEGG; bat:BAS3617; -.
DR   PATRIC; fig|198094.11.peg.3874; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000427; Chromosome.
DR   Proteomes; UP000000594; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..626
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009977"
FT   REGION          377..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   626 AA;  71456 MW;  1850CC3A345AB0FC CRC64;
     MGKIRKLDDQ LSNLIAAGEV VERPASVVKE LVENSIDANS TSIEIHLEEA GLSKIRIIDN
     GDGIAEEDCI VAFERHATSK IKDENDLFRI RTLGFRGEAL PSIASVSELE LITSTGDAPG
     THLIIKGGDI IKQEKTASRK GTDITVQNLF FNTPARLKYM KTIHTELGNI TDIVYRIAMS
     HPEVSLKLFH NEKKLLHTSG NGDVRQVLAS IYSIQVAKKL VPIEAESLDF TIKGYVTLPE
     VTRASRNYMS TIVNGRYVRN FVLMKAIQQG YHTLLPVGRY PIGFLSIEMD PMLVDVNVHP
     AKLEVRFSKE QELLKLIEET LQAAFKKIQL IPDAGVTTKK KEKDESVQEQ FQFEHAKPKE
     PSMPEIVLPT GMDEKQEEPQ AVKQPTQLWQ PSTKPIIEEP IQEEKSWDSN EEGFELEELE
     EVREIKEIEM NGNDLPPLYP IGQMHGTYIF AQNDKGLYMI DQHAAQERIN YEYFRDKVGR
     VAQEVQELLV PYRIDLSLTE FLRVEEQLEE LKKVGLFLEQ FGHQSFIVRS HPTWFPKGQE
     TEIIDEMMEQ VVKLKKVDIK KLREEAAIMM SCKASIKANQ YLTNDQIFAL LEELRTTTNP
     YTCPHGRPIL VHHSTYELEK MFKRVM