ID   MUTL_BACFR              Reviewed;         625 AA.
AC   Q64NX1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BF4069;
OS   Bacteroides fragilis (strain YCH46).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=295405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YCH46;
RX   PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA   Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA   Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT   "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT   regulating cell surface adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP006841; BAD50811.1; -; Genomic_DNA.
DR   RefSeq; WP_010993641.1; NC_006347.1.
DR   RefSeq; YP_101345.1; NC_006347.1.
DR   AlphaFoldDB; Q64NX1; -.
DR   SMR; Q64NX1; -.
DR   STRING; 295405.BF4069; -.
DR   PRIDE; Q64NX1; -.
DR   EnsemblBacteria; BAD50811; BAD50811; BF4069.
DR   KEGG; bfr:BF4069; -.
DR   PATRIC; fig|295405.11.peg.3916; -.
DR   HOGENOM; CLU_004131_4_0_10; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000002197; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..625
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000058134"
SQ   SEQUENCE   625 AA;  69033 MW;  AEC72AF3100FB554 CRC64;
     MSDIIHLLPD SVANQIAAGE VIQRPASVIK ELVENAIDAE AQNIHVLVTD AGKTCIQVID
     DGKGMSETDA RLSFERHATS KIREASDLFA LRTMGFRGEA LASIAAVAQV ELKTRPESEE
     LGTKIIIAGS KVESQEAVSC PKGSNFSIKN LFFNIPARRK FLKANSTELS NILAEFERIA
     LVHPEVAFSL YSNDSELFNL PACHLRQRIL SVFGKKLNQQ LLSVEVNTTM VKVSGYVAKP
     ETARKKGAHQ YFFVNGRYMR HPYFHKAVMD AYEQLIPAGE QISYFIYFEV DPANIDVNIH
     PTKTEIKFEN EQAIWQILSA SIKESLGKFN AVPSIDFDTE DMPDIPAFEQ NLPPAPPKVH
     FNSDFNPFKP SSSSGGGNYS RPKVDWEDLY GGLEKASKMN QPFSDSDPES EEFAVIEEES
     IATAAPETLY AGELAVIEKG TQHLQFKGRF ILTSVKSGLM LIDQHRAHIR VLFDRYRAQI
     QQKQGFSQGV LFPEILQLPA SEAAVLQSIM DDLSAVGFDL SDLGGGSYAI NGVPSGIDGL
     NPVDLVRSML HTAMEKGNDV KEEIQDILAL TLARAAAIVY GQVLSNEEMV SLVDNLFACP
     SPNYTPDGRV VLTTIKEEEI DKLFR