MUTL_BACMK
ID MUTL_BACMK Reviewed; 644 AA.
AC A9VS12;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN OrderedLocusNames=BcerKBAB4_3539;
OS Bacillus mycoides (strain KBAB4) (Bacillus weihenstephanensis).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=315730;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KBAB4;
RX PubMed=17434157; DOI=10.1016/j.cbi.2007.03.003;
RA Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C.,
RA Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V.,
RA Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "Extending the Bacillus cereus group genomics to putative food-borne
RT pathogens of different toxicity.";
RL Chem. Biol. Interact. 171:236-249(2008).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000903; ABY44712.1; -; Genomic_DNA.
DR RefSeq; WP_002142841.1; NC_010184.1.
DR AlphaFoldDB; A9VS12; -.
DR SMR; A9VS12; -.
DR STRING; 315730.BcerKBAB4_3539; -.
DR EnsemblBacteria; ABY44712; ABY44712; BcerKBAB4_3539.
DR KEGG; bwe:BcerKBAB4_3539; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_9; -.
DR OMA; AHERIMY; -.
DR Proteomes; UP000002154; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..644
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000096628"
FT REGION 340..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 73697 MW; 42D16F997689ED64 CRC64;
MGKIRKLDDQ LSNLIAAGEV VERPASVVKE LVENSIDANS TSIEIHLEEA GLSKIRIIDN
GDGIAEEDCI VAFERHATSK IKDENDLFRI RTLGFRGEAL PSIASVSELE LITSTGDAPG
THLSIKGGDI IKQEKTASRK GTDITVQNLF FNTPARLKYM KTIHTELGNI TDIVYRIAMS
HPEVSLKLFH NEKKLLHTSG NGDVRQVLAS IYSIQVAKKL IPIEAESLDF TIKGYVTLPE
VTRASRNYMS TIVNGRYVRN FVLMKAIQQG YHTLLPIGRY PIGFLSIEMD PMLVDVNVHP
AKLEVRFSKE QELLKLIEET LQSAFKKIQL IPDAGVTTKK KEKDESVQEQ FKFEHTKPRE
SSMPNIVLPT GMDEKQEETT TVKQPAQLWQ PPKQEWQPPQ SLVREEQSWQ PSSKPETVRE
EKEWTSNDDD FELEELEEEV GEIEEIEMNG NDLPPLYPIG QMHGTYIFAQ NDNGLYMIDQ
HAAQERINYE YFRDKVGRVT QEVQELLVPY RIDLSLTEFL RVEEQLEELK KVGLFLEQFG
HQSFIVRSHP TWFPKGQETE IIDEMMEQVV KLKKVDIKKL REEAAIMMSC KASIKANQYL
TNDQIFALLE ELRTTTNPYT CPHGRPILVH HSTYELEKMF KRVM