ID   MUTL_BACTN              Reviewed;         640 AA.
AC   Q8A120;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BT_3851;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE015928; AAO78956.1; -; Genomic_DNA.
DR   RefSeq; NP_812762.1; NC_004663.1.
DR   RefSeq; WP_008760778.1; NZ_UYXG01000011.1.
DR   AlphaFoldDB; Q8A120; -.
DR   SMR; Q8A120; -.
DR   STRING; 226186.BT_3851; -.
DR   PaxDb; Q8A120; -.
DR   PRIDE; Q8A120; -.
DR   EnsemblBacteria; AAO78956; AAO78956; BT_3851.
DR   GeneID; 60925026; -.
DR   KEGG; bth:BT_3851; -.
DR   PATRIC; fig|226186.12.peg.3915; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_0_10; -.
DR   InParanoid; Q8A120; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..640
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000058136"
SQ   SEQUENCE   640 AA;  70504 MW;  8EC9798C3B585E91 CRC64;
     MSDIIHLLPD SVANQIAAGE VIQRPASVIK ELVENAIDAD AQNIHVLVTD AGKTCIQIID
     DGKGMSETDA RLSFERHATS KIREAADLFA LRTMGFRGEA LASIAAVAQV ELKTRLESEE
     LGTKLVIAGS KVESQEAVSC SKGSNFSVKN LFFNVPARRK FLKANSTELS NILAEFERIA
     LVHPEVAFSL YSNDSELFNL PVSPLRQRIL AIFGKKLNQQ LLNIEVNTTM VKISGYIAKP
     ETARKKGAHQ YFFVNGRYMR HPYFHKAVME AYEQLIPVGE QVSYFIYFEV DPANIDVNIH
     PTKTEIKFEN EQAIWQILSA SVKESLGKFS AIPSIDFDTE DMPDIPAFEQ NLPPAPPKIH
     YNSDFNPFKV SSGGSGGGSY SRPKVEWEGL YGGLTKASKM NEPQQEPEMD WENSPFEEEP
     MVAEEKTISA VSAASSTFSS ASSTLYANES VIEKGNLHLQ FKGRFILTSV KSGLMLIDQH
     RAHIRVLFDR YMVQIKQKQG VSQGVLFPEI LQLPASEAAV LQGIMDDLSA VGFDLSDLGG
     GSYAINGIPS GIEGLNPVEL VRNMLHTAME KGNDVKEEIQ NILALTLARA AAIVYGQVLS
     NEEMVSLVDS LFACPSPNYT PDGKTVLTTI KEEDIEKLFK