ID   MUTL_BACVZ              Reviewed;         624 AA.
AC   A7Z4X6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=RBAM_016890;
OS   Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)
OS   (Bacillus amyloliquefaciens subsp. plantarum).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus amyloliquefaciens group.
OX   NCBI_TaxID=326423;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42;
RX   PubMed=17704766; DOI=10.1038/nbt1325;
RA   Chen X.H., Koumoutsi A., Scholz R., Eisenreich A., Schneider K.,
RA   Heinemeyer I., Morgenstern B., Voss B., Hess W.R., Reva O., Junge H.,
RA   Voigt B., Jungblut P.R., Vater J., Suessmuth R., Liesegang H.,
RA   Strittmatter A., Gottschalk G., Borriss R.;
RT   "Comparative analysis of the complete genome sequence of the plant growth-
RT   promoting bacterium Bacillus amyloliquefaciens FZB42.";
RL   Nat. Biotechnol. 25:1007-1014(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000560; ABS74052.1; -; Genomic_DNA.
DR   RefSeq; WP_012117587.1; NC_009725.2.
DR   AlphaFoldDB; A7Z4X6; -.
DR   SMR; A7Z4X6; -.
DR   STRING; 326423.RBAM_016890; -.
DR   EnsemblBacteria; ABS74052; ABS74052; RBAM_016890.
DR   KEGG; bay:RBAM_016890; -.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001120; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..624
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009975"
FT   REGION          355..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  70144 MW;  8C1F42809FC9C58A CRC64;
     MAKVIQLSDE LSNKIAAGEV VERPASVVKE LVENAIDANS TVIEIDIEEA GLSSIRVLDN
     GEGMETDDCK RAFRRHATSK IKDENDLFRV RTLGFRGEAL PSIASVSHLE IKTSIGEGAG
     THLILQGGNI ISEQKSSSRK GTEIIVTNLF FNTPARLKYM KTVHTELGNI TDVVNRIALA
     HPEVSIRLRH QGKNLLQTNG NGDVRHVLAA IYGTAVAKKM IPLHISSLDF EVKGYIALPE
     ITRASRNYMS SVINGRYIKN FPLVKAVHEG YHTLLPIGRH PITFIEITMD PILVDVNVHP
     SKLEVRLSKE TELHELIRDG IKEVFQKQRL IPSAQLPKKS APAPAKNEQQ FMTFEESAPE
     RKLPEKTPEP SYSPMKLSSV VKEPEPVIIE EEILPNEADH GVPPELGMPE TAAPVSDTPE
     PEAVSEEIRE ERVPMMYPIG QMHGTYILAQ NENGLYIIDQ HAAQERIKYE YFREKVGQVE
     PEVQDMIVPL TFHYAANEAL IIDQHQHELE SVGVFLEAFG TNSYIVRCHP AWFPKGEEAE
     LIEEIIQQVL DAKQIDIKKL REEAAIMMSC KGSIKANRHL RNDEIKALLD DLRRTTDPFT
     CPHGRPIIIH HSTYEMEKMF KRVM