ID   MUTL_BARBK              Reviewed;         611 AA.
AC   A1UU01;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=BARBAKC583_1201;
OS   Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=360095;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35685 / NCTC 12138 / KC583;
RA   Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S.,
RA   Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R.,
RA   Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J.,
RA   Fraser-Ligget C., Seshadri R.;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000524; ABM44985.1; -; Genomic_DNA.
DR   RefSeq; WP_005767876.1; NC_008783.1.
DR   AlphaFoldDB; A1UU01; -.
DR   SMR; A1UU01; -.
DR   STRING; 360095.BARBAKC583_1201; -.
DR   EnsemblBacteria; ABM44985; ABM44985; BARBAKC583_1201.
DR   KEGG; bbk:BARBAKC583_1201; -.
DR   PATRIC; fig|360095.6.peg.1170; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000643; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..611
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009984"
SQ   SEQUENCE   611 AA;  67261 MW;  EDFBF0577E31B5B6 CRC64;
     MIIRHLSENI INQIAAGEVI ERPANVIKEL VENAIDAQAT RIEISIVNGG KNFIRVSDNG
     CGIPADQLTL AVSRHCTSKI VDDVSNICFL GFRGEALPSI GSVAKLKLTS RTQDADNANE
     ISVIAGKIEG PKPAAANPGT IVEVRDLFFV TPARLKFMKT DRAETSAITD MIKRIAIAFP
     HIRFSLSSTD RMLMEFPATE NNTQGQLQRI TQIMGKEFAP NSIALNAERE SVRLTGFTCL
     PSFNRSNSLH QFAYVNGRPV RDKLLWGAIR GAYADAIARD RHAVSIIFID LPPADVDVNV
     HPTKADVRFR DPGLIRGLII GAIHEALHQA GVRHTSTHSE SVLTAFQIHP LENLKSAQRP
     FSYTSQPYHR VSTTTSMLQK PLDDSIDLRE GIVPMMECLS APSSDTRATI QTSPTEELHY
     PLGAAKAQIH KNYIISQTQD SLIIVDQHAA HERLVYEALK NALYSKPLSS QLLLIPEIVE
     LSEEDAACLL THKDSLQKFG LGIEPFGPGA ILVRETPAML GEINAQALIK DLADEAAEYD
     TTNNLKAMLD YVAATMACHS SVRSGRLLRP EEMNALLRQI EETPHSSTCN HGRPTYIELK
     LADIERLFGR K