ID   MUTL_BARHE              Reviewed;         612 AA.
AC   Q6G4R4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BH02690;
OS   Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)
OS   (Rochalimaea henselae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; BX897699; CAF27081.1; -; Genomic_DNA.
DR   RefSeq; WP_011180219.1; NZ_LRIJ02000001.1.
DR   AlphaFoldDB; Q6G4R4; -.
DR   SMR; Q6G4R4; -.
DR   STRING; 283166.BH02690; -.
DR   PaxDb; Q6G4R4; -.
DR   PRIDE; Q6G4R4; -.
DR   EnsemblBacteria; CAF27081; CAF27081; BH02690.
DR   GeneID; 64156568; -.
DR   KEGG; bhe:BH02690; -.
DR   eggNOG; COG0323; Bacteria.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000421; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..612
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009985"
SQ   SEQUENCE   612 AA;  66926 MW;  31B63D83D4521A63 CRC64;
     MIIRHLSENI INQIAAGEVI ERPANVVKEL VENAIDAEAT RIEIVTTNGG KNFIRVSDNG
     CGIPADQLTL AVSRHCTSKI TDDVHNICFL GFRGEALPSI GSVAKLKLTS RTQNAESAAE
     IIVTAGKIVG PKPAAANPGT IVEVRDLFFV TPARLKFMKT DRAETNSITD MIKRIAIAFP
     HIHFSLSGSD RTSLELPATA NNTQGQLQRI TQIMGKEFAP NSIVLNAERE SVRLTGFACL
     PSFNRSNSLH QFAYVNGRPV RDKFLWGAIR GAYADVMTRD RYPVSILFID LPPADVDVNV
     HPTKADVRFR DPGFIRGLIV GAIREALHHT GVRSTSTRSE AMLAAFQTQK PLKTFKSTYK
     PSSYSPQPYH VESASMVNKP LDIISPVGLK EDAPPLMEGL DIPSGDAYTP NTPAASEECS
     YPLGAARAQI HKNYIIAQTQ DSLIIVDQHA AHERLVYEAL KNALYSKPLP SQLLLIPEIV
     ELSEEDATCL LTHKDALQKF GLGIEAFGPG AIVVRETPSL LGEINVEALI KDLADEAAEY
     DTTDNLKTML DYVAATMACH GSIRSGRLLH PEEMNALLRQ IEATPNTGTC NHGRPTYIEL
     KLADIERLFG RK