ID   MUTL_BARQU              Reviewed;         612 AA.
AC   Q6G0J4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BQ02570;
OS   Bartonella quintana (strain Toulouse) (Rochalimaea quintana).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Toulouse;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; BX897700; CAF25760.1; -; Genomic_DNA.
DR   RefSeq; WP_011179069.1; NC_005955.1.
DR   AlphaFoldDB; Q6G0J4; -.
DR   SMR; Q6G0J4; -.
DR   STRING; 283165.BQ02570; -.
DR   EnsemblBacteria; CAF25760; CAF25760; BQ02570.
DR   KEGG; bqu:BQ02570; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000597; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..612
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009986"
SQ   SEQUENCE   612 AA;  66888 MW;  3342ABD9CA044851 CRC64;
     MIIRHLSENI INQIAAGEVI ERPANVVKEL VENAIDAGAT RIEIVTANGG KSFIKVSDNG
     CGIPADQLTL AISRHCTSKI TDDVHNIYFL GFRGEALPSI GSVAKLKLTS RTQEAENATE
     IIVTAGKIIG PKPAAANPGT IVEVRDLFFV TPARLKFMKT DRAETNAISD MIKRIAIAFP
     HIRFSLSGLD RTSMELPATA NSTQGQLQRI TQIMGKEFAP NSIALNAKRE SIRLTGFACL
     PSFNRSNSLH QFAYVNRRPV RDKFLWGTIR GAYADVMARD RYPVSILFID LPPADVDVNV
     HPTKADVRFR DPGLIRGLIV GAIHEALHQI GVRPASTCSE AMLSAFQTSQ PLGTFKSTHQ
     TFSSQHHHLA SAAASPLHKP LDATNFVNLR EEAVPLMECL DMPSGDICTA NTTPSSEELH
     YPLGAARAQI HKNYIIAQTQ DSLIIVDQHA AHERLVYEAL KDALYSKPLP SQLLLIPEIV
     ELSEEDATCL LTHKDALQKF GLGIESFGPG AIVVRETPSM LGEVNVQALI KDLADEAAEY
     DTTNNLKAMI DCVAATMACH GSIRSGRLLR AEEMNALLRQ IEATPHTGTC NHGRPTYIEL
     KLADIERLFG RK