ID   MUTL_BART1              Reviewed;         617 AA.
AC   A9IN82;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BT_0298;
OS   Bartonella tribocorum (strain CIP 105476 / IBS 506).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=382640;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIP 105476 / IBS 506;
RX   PubMed=18037886; DOI=10.1038/ng.2007.38;
RA   Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G.,
RA   Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.;
RT   "Genomic analysis of Bartonella identifies type IV secretion systems as
RT   host adaptability factors.";
RL   Nat. Genet. 39:1469-1476(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AM260525; CAK00764.1; -; Genomic_DNA.
DR   RefSeq; WP_012230736.1; NC_010161.1.
DR   AlphaFoldDB; A9IN82; -.
DR   SMR; A9IN82; -.
DR   STRING; 382640.BT_0298; -.
DR   EnsemblBacteria; CAK00764; CAK00764; BT_0298.
DR   KEGG; btr:BT_0298; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001592; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..617
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076689"
SQ   SEQUENCE   617 AA;  67555 MW;  D0BEE07BCCBDCA4B CRC64;
     MIIRHLSENI INQIAAGEVI ERPANVVKEL VENAIDAGAT RIEIITANGG KNFIKVSDNG
     CGIPADQLTL AVSRHCTSKI TDDVHNICFL GFRGEALPSI GSVAKLKLIS RTKEAENAAE
     ISVTAGKIVG PKPAAANLGT IVEVRDLFFV TPARLKFMKT DRAETNAISD MIKRIAIAFP
     HIRFSLSGLD RTSMELSATE NNTQGQLQRI TQIMGKEFAP NSIALDAERE SVRLTGFACL
     PSFNRNNSLH QFAYVNGRPV RDKFLWGAIR GAYADVMTRD RYPVAILFID LPPAEVDVNV
     HPAKADVRFR DPGLIRGLIV GAIREALQQS GIRPTSTRSE AMLAAFQTQK PLTQQSLGNF
     KNAHQSSSYS PQSHHFATAS MVHKPLDSTN SFGLKENATP IMEGLNTPSG DAYIPSTIPS
     SEELSYPLGA ARAQIHKNYI IAQTQDSLII VDQHAAHERL VYEALKNALY AKPLPSQLLL
     IPEIVELSEE DATCLLTHKD ALQKFGLGIE PFGPGAILVR ETPSMLGKIN VQALIKDLAD
     EAAEYDTTNN LKAMLDYVAA TMACHGSIRS GRLLRPEEMN RLLRQMEAIP NTSTCNHGRP
     TYIELKLADI ERLFGRK