ID   MUTL_BAUCH              Reviewed;         602 AA.
AC   Q1LSQ2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BCI_0584;
OS   Baumannia cicadellinicola subsp. Homalodisca coagulata.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Candidatus Baumannia.
OX   NCBI_TaxID=374463;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16729848; DOI=10.1371/journal.pbio.0040188;
RA   Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H.,
RA   Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A.;
RT   "Metabolic complementarity and genomics of the dual bacterial symbiosis of
RT   sharpshooters.";
RL   PLoS Biol. 4:1079-1092(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000238; ABF13838.1; -; Genomic_DNA.
DR   RefSeq; WP_011520745.1; NC_007984.1.
DR   AlphaFoldDB; Q1LSQ2; -.
DR   SMR; Q1LSQ2; -.
DR   STRING; 374463.BCI_0584; -.
DR   EnsemblBacteria; ABF13838; ABF13838; BCI_0584.
DR   KEGG; bci:BCI_0584; -.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; YLANYQT; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002427; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..602
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009987"
SQ   SEQUENCE   602 AA;  68415 MW;  D43D757EECE76624 CRC64;
     MQIHRLSPQL INQIAAGEVV ERPASVVKEL IENSLDAGAT RIDIEVELGG AKVIRIRDNG
     YGISKKDIVL AVARHTTSKI SSIEDLECIK SMGFRGEALA SISSVAHLNL TSRTAKQNEA
     WQVYTERYTE KVMLLPIAHP VGTTVEVLDL FYNTPARRKF MRAEQTEFKH IEEVIRRMAL
     ARFDVTFILQ HNNKIVQHYR AVKEPSQYWR RLSRLCGNTF VNNALKISWQ NIDFSIQGWV
     EDPSCIKLPE MQYSYVNQRI IRNKLINHAI RHAYQDQLKG PHQPSFVIFI VINPQQLDIN
     VHPAKKEIKF YEARKVHHFI YQALMTVLQQ RVKLSSDTCY STTQKPIGKI IPSHALNQLN
     EGKNNILVSY SAAAKNADEL LSNQIIQDPD EAKMQDIPAK CQATKNSCST SLSNDFYSFG
     KMLTFCSPCY ALLESAQGLS LLSLQFAERY ITERQLTPEN NSDTILAQPL LIPLRIILSN
     GEASALHQHR LLLQRMGILL QPNENETILN AVPLPLLRKK NLSNLILDLL RYLNNETSVT
     YHKIASWLAC SLNSQITTWN YSRAIPLIAE VERLCPHWIK NPPNALIVKL DLKMAIKALN
     NS