ID   MUTL_BORAP              Reviewed;         611 AA.
AC   Q0SNV1; G0IR53;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=BAPKO_0218, BafPKo_0211;
OS   Borreliella afzelii (strain PKo) (Borrelia afzelii).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=390236;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PKo;
RX   PubMed=16914037; DOI=10.1186/1471-2164-7-211;
RA   Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J.,
RA   Wilske B., Platzer M.;
RT   "Comparative genome analysis: selection pressure on the Borrelia vls
RT   cassettes is essential for infectivity.";
RL   BMC Genomics 7:211-211(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PKo;
RX   PubMed=22123755; DOI=10.1128/jb.05951-11;
RA   Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J.,
RA   Fraser-Liggett C.M., Schutzer S.E.;
RT   "Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii
RT   Lyme disease agent isolates.";
RL   J. Bacteriol. 193:6995-6996(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000395; ABH01477.1; -; Genomic_DNA.
DR   EMBL; CP002933; AEL69439.1; -; Genomic_DNA.
DR   RefSeq; WP_004790591.1; NC_017238.1.
DR   AlphaFoldDB; Q0SNV1; -.
DR   SMR; Q0SNV1; -.
DR   STRING; 390236.BafPKo_0211; -.
DR   PRIDE; Q0SNV1; -.
DR   EnsemblBacteria; AEL69439; AEL69439; BafPKo_0211.
DR   KEGG; baf:BAPKO_0218; -.
DR   KEGG; bafz:BafPKo_0211; -.
DR   PATRIC; fig|390236.22.peg.207; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_12; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000005216; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..611
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009989"
SQ   SEQUENCE   611 AA;  71410 MW;  00865F3029D00E58 CRC64;
     MNKIRFLDKY LVQKIAAGES IDRPCSILRE LLDNSIDSGA TKIEVFLEEG GIQKILIIDN
     GSGISQEDLK ICYLPHTTSK ISSEEDLRKI ETLGFRGEAL SSIAICSNIS ITSSTTGNES
     YQIEVENGIE KCFKKQPAIN GTIVDVTKIF HNFPARKRFL KQEPIETKMC LKVLEEKIIT
     HPEINFEINL NQKLRKIYFK ESLIDRVQNV YGNVIENNKF KVLKKEHENI KIEIFLAPAN
     FSKKSKRHIK TFVNRRPIDQ KDLLEAITNG HSRILSPGNF PICYLFLEIN PEYIDFNVHP
     QKKEVRFFNL PFLFKLISDN INNFFDKDTN NYHDVIIKRQ LTDDDHLIEM INQSENFNKT
     STYDVPQNKN LETEDNTNEP NKNMIQKDVG LRKYNSIIEN RPSLKENITN IFSDSFLEFE
     EPPNKNEEED IKFNYIGQIF SEFLIVEKAN EIYFIDQHAV HEKIIYEKLR NSKKTIQKLL
     IPIEFTIVDK NIEKIIDSEI EEYKKMDIII SKIGSEKYQL ESIPNICNQY ENTLINFFQS
     RRSRTINSLE SDLYATIACR KAVKTNDILS VEFSKYLINE FFKLEIKHCP HGRKIYYKIS
     KFELEKKVDR A