ID   MUTL_BORDL              Reviewed;         611 AA.
AC   B5RL36;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BDU_211;
OS   Borrelia duttonii (strain Ly).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=412419;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ly;
RX   PubMed=18787695; DOI=10.1371/journal.pgen.1000185;
RA   Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J.,
RA   Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M.;
RT   "The genome of Borrelia recurrentis, the agent of deadly louse-borne
RT   relapsing fever, is a degraded subset of tick-borne Borrelia duttonii.";
RL   PLoS Genet. 4:E1000185-E1000185(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000976; ACH93165.1; -; Genomic_DNA.
DR   RefSeq; WP_012537977.1; NC_011229.1.
DR   AlphaFoldDB; B5RL36; -.
DR   SMR; B5RL36; -.
DR   STRING; 412419.BDU_211; -.
DR   PRIDE; B5RL36; -.
DR   EnsemblBacteria; ACH93165; ACH93165; BDU_211.
DR   KEGG; bdu:BDU_211; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_12; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000611; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..611
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096630"
SQ   SEQUENCE   611 AA;  71526 MW;  CFDC16364993C7A4 CRC64;
     MNKIKFLDKT LVQKIAAGEA IDRPCSILRE LLDNAIDSGA DKIEVFIEEG GIRRILITDN
     GSGISKEDLK ICYLPHTTSK INEEKDLERI QTLGFRGEAL SSIAICSNLM ITSSTTGENS
     YQIEIENGIE KYFKKQSAIN GTMVDVTNLF HNFPARKRFL KKDSIETKMC LKVFEEKAVT
     HPGIDFKLSV NKELKKVYFK ESLADRVQSV YGEIIENNKF GKIEAEYDHV KMKIFFAPPN
     FSRKDRRNIK IFVNRRPIEE KSLSESIING HSRILTYKNF PVCYLFLEID TTHVDFNIHP
     QKKEVRFFNL PFLPKQISNN INEFFDREKQ EILQDYHNVI IKRQLTNDAH LLHPENDLTN
     SNFKTYEITQ DEALILDKPK NNKVTNIIED KVKFEGQIPQ KYKPSFKQHI QKIFIKTSKM
     PNNFQKSTQT NEFKYMGQLF SEFLIVENAN EIYFIDQHAL HEKIIYQTLI NSEKTIQKLL
     VPIEFQVECE DTDKILTSEL EEYKKIDIIV KKIQNQTYRL ESIPNICNKY ENIIIQFFKT
     RKSKIIDSLE TELYATLACR QAIKCNDTIS LEFSQFLINE FFNLKLKHCP HGRKIYHKIT
     KFELEKSVNR Q