MUTL_BORGP
ID MUTL_BORGP Reviewed; 611 AA.
AC Q662F3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BG0213;
OS Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 /
OS PBi) (Borrelia bavariensis).
OC Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX NCBI_TaxID=290434;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2496 / DSM 23469 / PBi;
RX PubMed=15547252; DOI=10.1093/nar/gkh953;
RA Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U.,
RA Schilhabel M., Wilske B., Suehnel J., Platzer M.;
RT "Comparative analysis of the Borrelia garinii genome.";
RL Nucleic Acids Res. 32:6038-6046(2004).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000013; AAU07068.1; -; Genomic_DNA.
DR RefSeq; WP_011193556.1; NC_006156.1.
DR AlphaFoldDB; Q662F3; -.
DR SMR; Q662F3; -.
DR STRING; 290434.BG0213; -.
DR EnsemblBacteria; AAU07068; AAU07068; BG0213.
DR KEGG; bga:BG0213; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_12; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000002276; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..611
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000009991"
SQ SEQUENCE 611 AA; 71442 MW; AB06BCE7734940DE CRC64;
MNKIRFLDKY LVQKIAAGES IDRPCSILRE LLDNSIDSGA TKIEVFLEEG GIHKILIIDN
GIGIGKEDLK ICYLPHTTSK ISSEEDLRKI ETLGFRGEAL SSIAICSNIS ITSSTTGNES
YQIEVENGIE KCFKKQPAIN GTIVNVTKIF HNFPARKRFL KQEPIETKMC LKVLEEKIIT
HPEINFEINL NQKLRKIYFK ESLIDRVQNV YGNVIENNKF KVLKKEHENI KIELFLAPAN
FSKKSKRHIK TFVNRRPIDQ KDLLEAITNG HSRIISPGNF PICYLFLEIN PEYIDFNVHP
QKKEVRFFNL PFLFKLISDN INNFFDKDIN SYNEIVIKRQ LTDDDNLIEM INQPKNLNKT
NTYDIIQNKN LETEHTVNDL SKNIIQNDIG LRRYNSIIQN RPSFKENITN IFSDKFLEFE
EPPNKNEKEE IKFNYIGQIF SEFLIVEKVN EIYFIDQHAV HEKIIYEKLR NSKKTVQKLL
IPIEFTIVDK NIEEIIDSEI EEYKKMDIII SKIGPKKYQL ESIPNICNQY ENTLINFFQS
RKSRTINSLE SDLYANIACR KAVKTNDILS LEFSKFLIDE FFKLEIKHCP HGRKIYYKIS
KFELEKKVAR A