MUTL_BORRA
ID MUTL_BORRA Reviewed; 611 AA.
AC B5RR29;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BRE_210;
OS Borrelia recurrentis (strain A1).
OC Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX NCBI_TaxID=412418;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A1;
RX PubMed=18787695; DOI=10.1371/journal.pgen.1000185;
RA Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J.,
RA Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M.;
RT "The genome of Borrelia recurrentis, the agent of deadly louse-borne
RT relapsing fever, is a degraded subset of tick-borne Borrelia duttonii.";
RL PLoS Genet. 4:E1000185-E1000185(2008).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000993; ACH94463.1; -; Genomic_DNA.
DR RefSeq; WP_012538738.1; NC_011244.1.
DR AlphaFoldDB; B5RR29; -.
DR SMR; B5RR29; -.
DR EnsemblBacteria; ACH94463; ACH94463; BRE_210.
DR KEGG; bre:BRE_210; -.
DR HOGENOM; CLU_004131_4_1_12; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000000612; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..611
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000096631"
SQ SEQUENCE 611 AA; 71602 MW; BD4A4E453DAA98E8 CRC64;
MNKIKFLDKT LVQKIAAGEA IDRPCSILRE LLDNAIDSGA DKIEVFIEEG GIRRILITDN
GSGISKEDLK ICYLPHTTSK INEEKDLERI QTLGFRGEAL SSIAICSNLM ITSSITGENS
YQIEIENGIE KYFKKQSAIN GTMVDVTNLF HNFPARKRFL KKDSIETKMC LKVFEEKAVT
HPGIDFKLSV NKELKKVYFK ESLADRVQSV YGEIIENNKF GKIEAEYDHV KMKIFFTPPN
FSRKDRRNIK IFVNRRPIEE KSLSESIING HSRILTYKNF PVCYLFLEID TTHVDFNIHP
QKKEVRFFNL PFLPKQISNN INEFFDREKQ EILQDYHNVI IKRQLTNDAH LLHPENDLTN
SNFKTYEITQ DEDLILDKPK NNKVTNIIED KVKFEGQISQ KYKPSFKQHI QKIFIKTSKM
PNNFQKSTQT NEFKYMGQLF SEFLIVENAN EIYFIDQHAL HEKIIYQTLI NSEKTIQKLL
VPIEFQVECE DTDKILTSEL EEYKKIDIIV KKIQNQTYRL ESIPNICNKY ENIIIQFFKT
RKSKIIDSLE TELYATLACR QAIKCNDTIS LEFSQFLINE FFNLKLKHCP HGRKIYHKIT
KFELEKSVNR Q