ID   MUTL_BORT9              Reviewed;         612 AA.
AC   A1QZ05;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BT0211;
OS   Borrelia turicatae (strain 91E135).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=314724;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91E135;
RA   Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T.,
RA   Schwan T.G.;
RT   "The genome sequence of Borrelia hermsii and Borrelia turicatae:
RT   comparative analysis of two agents of endemic N. America relapsing fever.";
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000049; AAX17547.1; -; Genomic_DNA.
DR   RefSeq; WP_011772166.1; NC_008710.1.
DR   AlphaFoldDB; A1QZ05; -.
DR   SMR; A1QZ05; -.
DR   STRING; 314724.BT0211; -.
DR   KEGG; btu:BT0211; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_12; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001205; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..612
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192162"
SQ   SEQUENCE   612 AA;  71558 MW;  38E92B6D08643A50 CRC64;
     MNKIKFLDRS LVQKIAAGEA IDRPCSILRE LLDNSIDSGA DKIEVFLEEG GIRRILITDN
     GSGISKEDLK ICYLPHTTSK INEEKDLEKI QTLGFRGEAL SSIAICSNLT ITSSTTGEDS
     YQIEVENGTE KYFKKQSAIN GTIVDVTNLF HNFPARKRFL KKDSIETKMC LKVFEEKAVT
     HPGIDFKLSL NNELRKVYFK ESLINRVQSV YGEIIENNKF GKIETEYENV QMKIFFAPPN
     FSRKDRRNIK IFLNRRPVEE HNLSEAIIDG HSRILTNRNF PICYLFLEID PRYVDFNIHP
     QKKEVRFFNL PFLPKQVSSN INEFFDRERK EILQDYHNII IKRQITNDAH LLHPEDDPTN
     SDFQTYEIIQ NESLILDKPQ NNKITNIIED KVKFESQNPI QKDKPSFKSY IQNILLETST
     IANDFQKPIA KHEFKYRGQL FSEFLIVEKD NEVFFIDQHA LHEKIIYQTL INSEKITQKL
     LIPIEFQVDC EDTDKILASE LEEYKKLDII VTKIKEQTYQ LESIPNICNK YENVIIQFFK
     TRKSKTIDSL ETDLYATIAC RQAVKCNDTI SSEFSQFLIN EFFNLKLKYC PHGRKIYHKI
     SKFELEKSVN RK