ID   MUTL_BRADU              Reviewed;         603 AA.
AC   Q89DE6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=blr7493;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000040; BAC52758.1; -; Genomic_DNA.
DR   RefSeq; NP_774133.1; NC_004463.1.
DR   RefSeq; WP_011090225.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q89DE6; -.
DR   SMR; Q89DE6; -.
DR   STRING; 224911.27355776; -.
DR   EnsemblBacteria; BAC52758; BAC52758; BAC52758.
DR   GeneID; 64027250; -.
DR   KEGG; bja:blr7493; -.
DR   PATRIC; fig|224911.44.peg.7593; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   InParanoid; Q89DE6; -.
DR   OMA; AHERIMY; -.
DR   PhylomeDB; Q89DE6; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..603
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009994"
SQ   SEQUENCE   603 AA;  65365 MW;  7E2F886ABCA6C568 CRC64;
     MPVRQLPEQV VNRIAAGEVV ERPASVVKEL VENAIDAGAS RIDVFTDGGG RRRIGITDDG
     SGMTAKDLAL AVERHATSKL DDEDLLQIRT LGFRGEALPS IGSVARLSIT TRHAGEPHAW
     ALTVEGGEKS EIMPAALAHG TRVEVNDLFY ATPARLKFLK TDRTEAEAIR EVVRRLAMAR
     PDVAFTLAGE ERAPVTWAAA LPGAAGRLTR LGDILGAEFR SHAIEVHAER EGIVVSGYAA
     APALTKANAL GQYLFVNGRP VRDKLILGAV RAAYSDYLPR DRHPVLALFV TLDPREVDAN
     VHPAKTEVRF RNAGLVRALI VHGLKEALAR EGRRTAANSG ESALSSFRPA FTPRPASWDW
     RASPSAPVAP MPSFDGAAAP AFTERAQAAF DVGAPSADVR FETQPVSDLV DRPLGAARTQ
     IHETYIVSQT RDGLIIVDQH AAHERIVYEG LKASLAANGV QRQILLIPEI VEMDEATVER
     LLERSDELAS FGLAIESFGP GAVAVRETPS LLGKTNAGGL LRDLSEHMAE WDEALPLERR
     LMHVAATMAC HGSVRAGRRL RPEEMNALLR EMEETPNSGQ CNHGRPTYVE LKLSDVEKLF
     GRR