ID   MUTL_BRASO              Reviewed;         613 AA.
AC   A4Z0Q5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BRADO6079;
OS   Bradyrhizobium sp. (strain ORS 278).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium; unclassified Bradyrhizobium.
OX   NCBI_TaxID=114615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ORS 278;
RX   PubMed=17540897; DOI=10.1126/science.1139548;
RA   Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C.,
RA   Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA   Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA   Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E.,
RA   Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA   Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT   "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL   Science 316:1307-1312(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CU234118; CAL79731.1; -; Genomic_DNA.
DR   RefSeq; WP_012029623.1; NC_009445.1.
DR   AlphaFoldDB; A4Z0Q5; -.
DR   SMR; A4Z0Q5; -.
DR   STRING; 114615.BRADO6079; -.
DR   EnsemblBacteria; CAL79731; CAL79731; BRADO6079.
DR   KEGG; bra:BRADO6079; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   BioCyc; BSP114615:BRADO_RS28280-MON; -.
DR   Proteomes; UP000001994; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..613
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000009996"
SQ   SEQUENCE   613 AA;  66420 MW;  44300ECE7B939434 CRC64;
     MPVRQLPEQV INRIAAGEVV ERPASVVKEL VENAIDAGAS RIDIFTDGGG RRKIAITDDG
     GGMTAADLAL AVERHATSKL DDEDLLQIRT LGFRGEALPS IGSVARLSIT TRHKSEPHAW
     GITVDCGDKS QIVPAALNQG TRVEVADLFH ATPARLKFLK TDRTEAEAIR EVVRRLAMAR
     PDIAFTVAGE ERAPVTWAAA LPGAPGQLTR LGDILGTDFR SHAIAVRSER DHVAVEGFAA
     APALTRANAL GQYLFVNGRP VRDKLILGAV RAAYADYLPR DRHPVVALFV TLDPREVDAN
     VHPAKTEVRF RNAGLVRALI IHALKEGLAR EGRRTAANDG GATIAAFRPA FTPPRPSAGP
     MNWDWQRSPS APIPRHDDVD SMPPAVSSAA FAEPMQAAFD VGGPRADLRL HEQPAAPDML
     DRPLGAARTQ IHDTYIVSQT RDGLVIVDQH AAHERIVYER LKTSLAAHGV QRQILLIPDI
     VELDEATVEA LLARTDELAA FGLAVESFGP GAVAVRETPS LLGKINAAGL LRDLAEHMEE
     WGEALPLERR LMHVAATMAC HGSVRAGRRL KPEEMNALLR VMEETPNSGQ CNHGRPTYVE
     LKLADVEKLF GRR