ID   MUTL_BRUA4              Reviewed;         626 AA.
AC   A6X3F3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Oant_3049;
OS   Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 /
OS   LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) (Ochrobactrum anthropi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=439375;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC
RC   15819 / NCTC 12168 / Alc 37;
RX   PubMed=21685287; DOI=10.1128/jb.05335-11;
RA   Chain P.S., Lang D.M., Comerci D.J., Malfatti S.A., Vergez L.M., Shin M.,
RA   Ugalde R.A., Garcia E., Tolmasky M.E.;
RT   "Genome of Ochrobactrum anthropi ATCC 49188 T, a versatile opportunistic
RT   pathogen and symbiont of several eukaryotic hosts.";
RL   J. Bacteriol. 193:4274-4275(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000759; ABS15757.1; -; Genomic_DNA.
DR   RefSeq; WP_011982765.1; NC_009668.1.
DR   AlphaFoldDB; A6X3F3; -.
DR   SMR; A6X3F3; -.
DR   STRING; 439375.Oant_3049; -.
DR   EnsemblBacteria; ABS15757; ABS15757; Oant_3049.
DR   KEGG; oan:Oant_3049; -.
DR   PATRIC; fig|439375.7.peg.3200; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   PhylomeDB; A6X3F3; -.
DR   Proteomes; UP000002301; Chromosome 2.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..626
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010051"
FT   REGION          352..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   626 AA;  67155 MW;  2B6ADA73C5741A77 CRC64;
     MPIRHLSETI INQIAAGEVI ERPASVIKEL VENAIDAGAT RIEVVTGGGG KTLLRVTDNG
     SGIPVDELPL AVSRHCTSKL SDDVHDIRAL GFRGEALPSI GSVAKLTLKS RPQDADSGFE
     VSVSGGHLDG PRPSALNRGT IAEVRDLFFA TPARLKFMKT DRAEASAITD VVKRIAIAFP
     HVRFSLAGTD RTPLELAATG SGAEATLERI NQVLGKEFGE NALAIDAERD GVRLAGFVGI
     PSHNRGNALH QFAYVNGRPV RDKQLFGALR GAYADVMARD RHPVAVLFLT LDPAFVDVNV
     HPAKADVRFR DPGLVRGLIV GAIKQALAQS GIRPATSGAD AMLQAFRAEG FQPPSPSFTS
     RPSSAGYASG SWHPAVSSPR TEWSPQTAHP AHRPLDLGAA PSFQESDQAT LATVNVLAAD
     ARATRDEAPV ELQQKPLGAA RAQIHANYIV SQTEDSLVIV DQHAAHERLV YEALKNALHS
     RPISGQMLLI PEIVDLPEED AERLATHAET LARFGLGIEQ FGPGAIAVRE TPAMLGEMNV
     QQLIRDLSDE IAEHDTSEGL KAMLNHVAAT MACHGSVRSG RRLKPEEMNA LLREMEATPG
     SGTCNHGRPT YIELKLTDIE RLFGRR