ID   MUTL_BRUMB              Reviewed;         623 AA.
AC   C0RKF6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BMEA_B0218;
OS   Brucella melitensis biotype 2 (strain ATCC 23457).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=546272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23457;
RA   Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J.,
RA   Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E.,
RA   Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C., Tapia R.,
RA   Han C., Detter J.C., Bruce D., Brettin T.S.;
RT   "Brucella melitensis ATCC 23457 whole genome shotgun sequencing project.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001489; ACO02089.1; -; Genomic_DNA.
DR   RefSeq; WP_004686161.1; NC_012442.1.
DR   AlphaFoldDB; C0RKF6; -.
DR   SMR; C0RKF6; -.
DR   EnsemblBacteria; ACO02089; ACO02089; BMEA_B0218.
DR   KEGG; bmi:BMEA_B0218; -.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001748; Chromosome II.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..623
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192163"
FT   REGION          353..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   623 AA;  66794 MW;  3C8EAC124772300E CRC64;
     MTIRHLSETI INQIAAGEVI ERPASVIKEL VENAIDAGAT RIEVVTAGGG KTLLRVTDNG
     SGIPADELAL AVSRHCTSKL TDDVHDIRAL GFRGEALPSI GSVSKLTLKS RPQDADSGFE
     VCVTGGHLDG PRPTALNRGT IVEVRDLFYA TPARLKFMKT DRAEATAITD VVKRIGIAFP
     HIRFSLAGTD RTPFEMPATG TGAEATLERI GQVLGREFGE NALAIDAERD GVRLAGFVGI
     PSFNRGNALH QFAYVNGRPV RDKQIFGALR GAYSDVIARD RHPVAVLFLT LDPALVDVNV
     HPAKADVRFR DPGLVRGLIV GAIKQALAQS GIRPATSGAE AMLQAFRAEG FGAQQSAPRP
     ANSYSPASWR TAPPAPRSEW SPQTAQTAHR PLDLQAAPAL RENGQAVLGD VAVPASDARA
     SVAEAPVELM QKPLGAARAQ IHENYIVAQT EDSLVIVDQH AAHERLVYEA LKNALHARPI
     AGQMLLIPEI VDLPEEDAQR LAGHAETLAR FGLGVEQFGP GAIAVRETPA MLGEMNVQQL
     IRDLADEIAE HDTADGLKAM LHHVAATMAC HGSVRSGRRL KPEEMNALLR DMEATPGSGT
     CNHGRPTYIE LKLTDIERLF GRR