MUTL_BUCA5
ID MUTL_BUCA5 Reviewed; 584 AA.
AC B8D8D4;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BUAP5A_563;
OS Buchnera aphidicola subsp. Acyrthosiphon pisum (strain 5A).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=563178;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5A;
RX PubMed=19150844; DOI=10.1126/science.1167140;
RA Moran N.A., McLaughlin H.J., Sorek R.;
RT "The dynamics and time scale of ongoing genomic erosion in symbiotic
RT bacteria.";
RL Science 323:379-382(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP001161; ACL30910.1; -; Genomic_DNA.
DR RefSeq; WP_009874518.1; NC_011833.1.
DR AlphaFoldDB; B8D8D4; -.
DR SMR; B8D8D4; -.
DR KEGG; bap:BUAP5A_563; -.
DR HOGENOM; CLU_004131_5_1_6; -.
DR OMA; YLANYQT; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000006904; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..584
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000192164"
SQ SEQUENCE 584 AA; 68389 MW; 0ADF51B7C9C0ABC8 CRC64;
MPIRILPSDL SSQISAGEII ERPASVVKEI IENSIDAGSK NINIIVENSG FQSIILKDDG
CGIDKKDLLL AVCHHATSKI NSLSDLDKLT TFGFRGEALA SIRAVSRLTL ISCTRFNDVA
AKIYLEGFCS KNIILQPIAH PEGTTIIVDN LFYNIPVRLK FLKNKKLEFS KICEVVKKIA
LSHFYINFSL KHNNKLITQY NSINNRKNKI NRLKDIFDTL DTSEFLEIKE KKYRMVLFGW
ISHPYNFKKI KNIQYCYVNN RYLYNNIFVN AVRAAYSKIE QKKNISFVLY LTIESFNIDI
NIHPTKNEIK FHNPDVVYTF IYEAVFSYLK KIKEKYYFNF SCKKQTQLNK EKEFYFYDSD
PTFLTLISSI FFKKKQIFKN IKNKIKHNNF ISKSTPLEKY ESSIGRLLII IHKYYGLIYH
DNNFLLLSFP VAKGIVRKQK LKNNIQKENI IEYFLSNIKI NLTSQEYLIL FNKKEILSKF
GFHLIFKKKY VILSSIPAFL KKCNFHIIIS NFFAFLFLKK QVFISDIVDW FYINVFIELK
NWTYIRGIEV LLEIEYYCPL LLINPPSKLL QKININAALC ILKI