ID   MUTL_BUCAI              Reviewed;         584 AA.
AC   P57633;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL; OrderedLocusNames=BU570;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; BA000003; BAB13260.1; -; Genomic_DNA.
DR   RefSeq; NP_240374.1; NC_002528.1.
DR   RefSeq; WP_010896167.1; NC_002528.1.
DR   AlphaFoldDB; P57633; -.
DR   SMR; P57633; -.
DR   STRING; 107806.10039226; -.
DR   EnsemblBacteria; BAB13260; BAB13260; BAB13260.
DR   KEGG; buc:BU570; -.
DR   PATRIC; fig|107806.10.peg.573; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; YLANYQT; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..584
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177931"
SQ   SEQUENCE   584 AA;  68311 MW;  DA28ED423D1CBF3C CRC64;
     MPIRILPSDL SSQISAGEII ERPASVVKEI IENSIDAGSK NINIIVENSG FQSIILKDDG
     CGIDKKDLLL AVCHHATSKI NSLSDLDKLT TFGFRGEALA SIRAVSRLTL ISCTRFNDVA
     AKIYLEGFCS KNIILQPIAH PEGTTIIVDN LFYNIPVRLK FLKNKKLEFS KICEVVKKIA
     LSHFYINFSL KHNNKLITQY NSINNRKNKI NRLKDIFDTL DTSEFLEIKE KKYRMVLFGW
     ISHPYNFKKI KNIQYCYVNN RYLYNNIFVN AVRAAYSKIE QKKNISFVLY LTIESFNIDI
     NIHPTKNEIK FHNPDVVYTF IYEAVFSYLK KIKEKYYFNF SCKKQTQLNK EKEFYFYDSD
     PTFLTLISSI FLKKKQICKN IKNKIKHNNF ISKSTPLEKY ESSIGRLLII IHKYYGLIYH
     DNNFLLLSFP VAKGIVRKQK LKNNIQKENI IEYFLSNIKI NLTSQEYLIL FNKKEILSKF
     GFHLIFKKKY VILSSIPAFL KKCNFHIIIS NFFAFLFLKK QVFISDIVDW FYINVFIELK
     NWTYIRGIEV LLEIEYYCPL LLINPPSKLL QKININAALC ILKI