ID   MUTL_BUCAP              Reviewed;         582 AA.
AC   Q8K913;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=BUsg_550;
OS   Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=198804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg;
RX   PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE013218; AAM68088.1; -; Genomic_DNA.
DR   RefSeq; WP_011054054.1; NC_004061.1.
DR   AlphaFoldDB; Q8K913; -.
DR   SMR; Q8K913; -.
DR   STRING; 198804.BUsg_550; -.
DR   PRIDE; Q8K913; -.
DR   EnsemblBacteria; AAM68088; AAM68088; BUsg_550.
DR   KEGG; bas:BUsg_550; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; YLANYQT; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000416; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..582
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177932"
SQ   SEQUENCE   582 AA;  67945 MW;  BA768F8E8AAF85E5 CRC64;
     MQPIRMLSSS LSSQISAGEV IERPSSVIKE LLENSIDAQA KNIDISVERS GLNSITVKDD
     GFGIEKDQLL LAISRHATSK INRLSDLDNI NTFGFRGEAL ASIRAVSRMK LISCSQNSNI
     AWSIYSEGFS NHTLLQPIAH PIGTSIIVDN LFYNIPVRLK FIKNERSEFL KIDETIKKIA
     LSNFGINIFF KKDKKLFVSY KAITKNNNKI HRLKTVFNQI DLNYVLEIKE KMHNITLFGW
     LIFPSSLSST FKKIQYCYVN NRFVYNNLIK SAVFNSFYEI IGNKRSTSFI LYLTLPSNEI
     DINIHPTKNE IKFHKSNIIY FFVYQSILSS LKKCKIKYIS NNFFLKTHSN KCKNNNSDSL
     NTKLVSQIHS KYEKKDLYKD VISTDLFKIN SQRFLKEYFF SFGKLLIVFQ KYYGLMYYSN
     TFSLISFPLA KKIVEQYKLR SAIKNNMIPE IFSYNFLYFI TFKQNKILSN NLKLLLKFGF
     NLILKEKYFF LKTIPIFLKN QNLDVLLSSF FSFIFFKKKI YIKDIIKWFD TTILIEKNSW
     NYEDGISILL EIEYFCPSIF KKPPLKLLQK INVDEVLCIL KV