ID   MUTL_BUCAT              Reviewed;         584 AA.
AC   B8D891;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=BUAPTUC7_564;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=561501;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuc7;
RX   PubMed=19150844; DOI=10.1126/science.1167140;
RA   Moran N.A., McLaughlin H.J., Sorek R.;
RT   "The dynamics and time scale of ongoing genomic erosion in symbiotic
RT   bacteria.";
RL   Science 323:379-382(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001158; ACL30356.1; -; Genomic_DNA.
DR   RefSeq; WP_012619586.1; NC_011834.1.
DR   AlphaFoldDB; B8D891; -.
DR   SMR; B8D891; -.
DR   PRIDE; B8D891; -.
DR   KEGG; bau:BUAPTUC7_564; -.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; YLANYQT; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..584
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192165"
SQ   SEQUENCE   584 AA;  68389 MW;  3DD2E76CA467B7B5 CRC64;
     MPIRILPSDL SSQISAGEII ERPASVVKEI IENSIDAGSK NINIIVENSG FQSIILKDDG
     CGIDKKDLLL AVCHHATSKI NSLSDLDKLT TFGFRGEALA SIRAVSRLTL ISCTRFNDVA
     AKIYLEGFCS KNIILQPIAH PEGTTIIVDN LFYNIPVRLK FLKNKKLEFS KICEVVKKIA
     LSHFYINFSL KHNNKLITQY NSINNRKNKI NRLKDIFDTL DTSEFLEIKE KKYRMVLFGW
     ISHPYNFKKI KNIQYCYVNN RYLYNNIFVN AVRAAYSKIE QKKNISFVLY LTIESFNIDI
     NIHPTKNEIK FHNPDVVYTF IYEAVFSYLK KIKEKYYFNF SCKKQTQLNK EKEFYFYDSD
     PTFLTLISSI FFKKKQIFKN IKNKIKHNNF ISKSTPLEKY ESSIGRLLII IHKYYGLIYH
     DNNFLLLSFP VAKGIVRKQK LKNNIQKENI IEYFLSNIKI NLTSQEYLIL FNQKEILSKF
     GFHLIFKKKY VILSSIPAFL KKCNFHIIIS NFFAFLFLKK QVFISDIVDW FYINVFIELK
     NWTYIRGIEV LLEIEYYCPL LLINPPSKLL QKININAALC ILKI