ID   MUTL_BUCBP              Reviewed;         597 AA.
AC   Q89A38;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL; OrderedLocusNames=bbp_515;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; AE016826; AAO27218.1; -; Genomic_DNA.
DR   RefSeq; WP_011091619.1; NC_004545.1.
DR   AlphaFoldDB; Q89A38; -.
DR   SMR; Q89A38; -.
DR   STRING; 224915.bbp_515; -.
DR   EnsemblBacteria; AAO27218; AAO27218; bbp_515.
DR   GeneID; 56471090; -.
DR   KEGG; bab:bbp_515; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..597
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177933"
SQ   SEQUENCE   597 AA;  68941 MW;  51EB836BCB1A4734 CRC64;
     MFIKILPLST SSYISAGEVI CNPASVVKEL MENSIDSSAT CIHIEIKKGG LQSIVVKDNG
     CGIDKSDLKA SLLHHATSKI YSVCDLNNIT TLGFRGEALA SISAVSRIIL SSCNISSKKV
     GWSIYSDGFG VISVPKLVVH NKGTICTVLD LFFNRPVRQK TIKSEYSEFL RIDEIVRSLS
     LSNNKLSVSL RHNDKLIRYY DNCNIDFCNI NMLNAIYGLS SVIKVVPVDY FLNTMKITGW
     LYLLGSYHTS KKKFQYFYIN GRIILNRSVH HAVYQAVSEI NHYQYSVSYI LYLKLNCNEL
     DVNIHPAKKI IKIINIRLIH VFICQAILYS LKKECILKKD CTKIIKNISN NKKKNNLNYN
     FQSNLDITSC IVQENSYSIP QKLFNLDNVS IIETELKFKR FKCKDYLNTI FGNVLMVIKN
     FYLLIEKNDE LFLFFLPRAK SLICELKLKF GVKNGLLIKK LRKKYFYFFK NNTEYHFFLR
     FYEILSHVGL NFNITLKYAE LNSIPFMIDD TNLGIIISEI LYFFKIKREM SLSRLVTTIM
     NHSKILVKYW DHLQVLSVIS ECEKYYKSIL ELNVISYILQ PINFDSTVNF FKNDSKV