ID   MUTL_CALS4              Reviewed;         590 AA.
AC   Q8RA70;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=TTE1358;
OS   Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM
OS   11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Caldanaerobacter.
OX   NCBI_TaxID=273068;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX   PubMed=11997336; DOI=10.1101/gr.219302;
RA   Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y.,
RA   Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R.,
RA   Wang J., Yu J., Yang H.;
RT   "A complete sequence of the T. tengcongensis genome.";
RL   Genome Res. 12:689-700(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE008691; AAM24580.1; -; Genomic_DNA.
DR   RefSeq; WP_011025653.1; NC_003869.1.
DR   AlphaFoldDB; Q8RA70; -.
DR   SMR; Q8RA70; -.
DR   STRING; 273068.TTE1358; -.
DR   PRIDE; Q8RA70; -.
DR   EnsemblBacteria; AAM24580; AAM24580; TTE1358.
DR   KEGG; tte:TTE1358; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000555; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..590
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177987"
SQ   SEQUENCE   590 AA;  67196 MW;  A5D01FB21A8A585E CRC64;
     MNKIHLLDEK TVNKIAAGEV VERPASIVKE LVENSIDAGS KNITVEILEG GIPYIKVTDD
     GCGMNEIDAV LAFERHATSK IRSDEDLFNI TTLGFRGEAL ASIAAVSKVV LQTKEENETF
     GTRLVVEGGK ILEKTRCGCQ KGTSVEVKDV FFNTPARRKF LKRPSTEAMY VTEVVTRLCL
     SNPGISFKYV KDKKVQFITS GNGSIEDVIL RLFGKEVHSA LIFSEFEAED LKVKAFATKN
     FLNYSNRNMQ FFYVNGRYVK NKTLSAAVDE AFKTYVPSDR YPGVFLYLEI NPRFIDVNIH
     PSKLEVKFSD DRRIFESVYR TIREALRESN LIPEVKLEKD LKNEEGQIGE QVKLSLPLFE
     VKEKTDDGAI FVREEVKTEE KIDKAPKHES SSDSERNVKR LSDIRIVGTL FSTYVIVEKG
     DVFYIIDQHA AHERILYEKL VSQYERVQSR QVTFPIVVEL QPGDMEIVGQ ERELLYKLGY
     VFEEFGNNSV VLREVPVILG QPEAKKLFVE IVERLRDKDF SSKVSFKEEE IATMACKAAV
     KAMDTLSENE IYKLFEDLKI AENPYTCPHG RPVIISMTKT QLEKMFKRIK