MUTL_CARHZ
ID MUTL_CARHZ Reviewed; 578 AA.
AC Q3ACA6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CHY_1396;
OS Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 /
OS Z-2901).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Carboxydothermus.
OX NCBI_TaxID=246194;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-161 / DSM 6008 / Z-2901;
RX PubMed=16311624; DOI=10.1371/journal.pgen.0010065;
RA Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J.,
RA Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J.,
RA Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.;
RT "Life in hot carbon monoxide: the complete genome sequence of
RT Carboxydothermus hydrogenoformans Z-2901.";
RL PLoS Genet. 1:563-574(2005).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000141; ABB15228.1; -; Genomic_DNA.
DR AlphaFoldDB; Q3ACA6; -.
DR SMR; Q3ACA6; -.
DR STRING; 246194.CHY_1396; -.
DR EnsemblBacteria; ABB15228; ABB15228; CHY_1396.
DR KEGG; chy:CHY_1396; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_9; -.
DR OMA; AHERIMY; -.
DR Proteomes; UP000002706; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..578
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000010000"
SQ SEQUENCE 578 AA; 65646 MW; 5EFD09FF60B56286 CRC64;
MPKIKRLPDE VIKKIAAGEV VERPYSVVKE LVENSLDAKA QNINVYIEEG GLGKIVVEDD
GIGIPPEELP DALLRHTTSK IASFDDLYYL ESFGFRGEAL YSIAAVSKIS IKSRVRGENN
GYELIAHAGE VINLTEVGMA YGTVVTVSDL FFNTPARKKF LKSGQTEAGL IRQFIEKMAI
LYPGVKFSLF IDGKKIYSSA GIQEQLGLLA RFWGLEKGNL LMLEEKLGEG FFIKGGIALP
PAGKPHRKLQ VFAVNKRLVK SGILTKAIDD AYESLLPTGL KPLVFLEVVV PGTWVDVNVH
PQKLEVKFMD EQKIYLDVRT IIRNKLVNAK SSSLKSFSPA RETNTKSEDN DYWQVTYFAE
EFSGNSDKLL EKEDIFSTSD NLTFSLNKDF AKELNFQVIG QFSLKYIIVE KNDKLLIIDQ
HAAHERILYE KYQTKLNPFY SQVLTFPVRI KASPELEAFL QENYQNFLEI GLHIEPFGPG
EYLVREIPED FPQNNIANVL EEYLYEIMEQ KEQVSFREKA LKLFACKNAV KFGEKLTYSE
MTNLVKELFK TNYPLSCPHG RPTIYELSLT EINKKFFR