ID   MUTL_CAUSK              Reviewed;         643 AA.
AC   B0SWX9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Caul_4062;
OS   Caulobacter sp. (strain K31).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter; unclassified Caulobacter.
OX   NCBI_TaxID=366602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K31;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Stephens C., Richardson P.;
RT   "Complete sequence of chromosome of Caulobacter sp. K31.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000927; ABZ73187.1; -; Genomic_DNA.
DR   RefSeq; WP_012288078.1; NC_010338.1.
DR   AlphaFoldDB; B0SWX9; -.
DR   SMR; B0SWX9; -.
DR   STRING; 366602.Caul_4062; -.
DR   EnsemblBacteria; ABZ73187; ABZ73187; Caul_4062.
DR   KEGG; cak:Caul_4062; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..643
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076692"
SQ   SEQUENCE   643 AA;  68482 MW;  FA53BD2A0249CE7F CRC64;
     MPIRRLPPET VNRIAAGEVV ERPASAIKEL VDNAIDAGAT RIEVEAHGGG LTRILVADDG
     CGLSAEELPV ALERHATSKL APDAQGLWDL LAIHTMGFRG EALPSIGSVA RLSISSRAKG
     SSDAWSILVE GGSVGDVAPA AFAGDHGARI EVRDLFYATP ARLKFMKSER AEALAITEEI
     KRQAMANESV GFSLDIDGRR IIRLPPEHPG PQGRLARLSA VLGRDFQDNA IEIDQTRDGV
     RLTGFAGLPT YNRGNAAHQY LFVNGRPVRD RLLQGALRAA YADFLARDRH PTAALYISLD
     TSEVDVNVHP AKAEVRFRDP ALVRGLIVGA LRHALAGAGH RASTTTAASA LDAIRAQSMV
     PPGAYSGYQP NAYQGGPSPA GFSAWQAGGW TRPSPQVLPG LSDVSARVEP GGYGVAEAVR
     EAAFGEYDAP PNVAYPGGFS EDPAPVFDPV DFPLGAARAQ VHETYIVAQT RDGVVIVDQH
     AAHERLVYER MKGEMAAGRV ARQALLLPEV VELDPAEAER VVARAEELAA LGLVIESFGP
     GAVLVRETPA LLGKTDAAGL VRDIADDLAE NGQALALKER LEEVCSTMAC HGSVRAGRRL
     TGAEMNALLR EMEATPHSGQ CNHGRPTYVE LKLADIERLF GRR