ID   MUTL_CAUVC              Reviewed;         637 AA.
AC   P0CAV5; Q9RP66;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL; OrderedLocusNames=CC_0695;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; AE005673; AAK22680.1; -; Genomic_DNA.
DR   PIR; D87335; D87335.
DR   RefSeq; NP_419512.1; NC_002696.2.
DR   RefSeq; WP_010918581.1; NC_002696.2.
DR   AlphaFoldDB; P0CAV5; -.
DR   SMR; P0CAV5; -.
DR   STRING; 190650.CC_0695; -.
DR   EnsemblBacteria; AAK22680; AAK22680; CC_0695.
DR   KEGG; ccr:CC_0695; -.
DR   PATRIC; fig|190650.5.peg.704; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   BioCyc; CAULO:CC0695-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..637
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177934"
SQ   SEQUENCE   637 AA;  68498 MW;  77F9B28AB4B0F1B6 CRC64;
     MPIRRLPPET VNRIAAGEVV ERPASAIKEL VDNAIDAGAT RIEVEAHGGG LTRILVADDG
     CGLSPEELPV AIERHATSKL APDADGLWDL LRIHTMGFRG EALPSIGSVA RLQISSRAKG
     AKDAFSILVE GGQVGEVAPA AFPGPHGARI EVRDLFYATP ARLKFMKSER AEALAITEEI
     KRQAMANESV GFSLDIDGRR VLRLPPEHPG PQGRLARLAA VLGREFQENA LEIDQTRDGV
     RLSGFAGLPT YNRGNAAHQY LFVNGRPVRD RLLQGALRAA YADFLARDRH PTAALYVTLE
     TTEVDVNVHP AKAEVRFRDP ALVRGLIVGA LRHALAGAGH RASTTVAAQA LDSIRAQQSP
     FPGYQPQYQP GPSPAGFSAW REGGWTPPTQ RPMDLPGLNE VSARVEPSYG GDLAGVVREA
     YAAAAFEDRP PTDYPGATAP FDPVDYPLGA ARAQVHETYI VAQTRDGMVI VDQHAAHERL
     VYERMKGEMA SGGVTRQTLL LPEVVDLDPA EAERVVARAE ELAGLGLVLE SFGPGAVLVR
     ETPALLGKTD AAALVRDIAD DLAENGQALA LKERLEEVCS TMACHGSVRA GRRLNGAEMN
     ALLREMEATP HSGQCNHGRP TYVELKLADI EKLFGRR