MUTL_CAUVN
ID MUTL_CAUVN Reviewed; 637 AA.
AC B8H173; Q9RP66;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=DNA mismatch repair protein MutL;
GN Name=mutL; OrderedLocusNames=CCNA_00731;
OS Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=565050;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA1000 / CB15N;
RX PubMed=20472802; DOI=10.1128/jb.00255-10;
RA Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA Walunas T.L., Crosson S.;
RT "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL J. Bacteriol. 192:3678-3688(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 112-637.
RX PubMed=10498730; DOI=10.1128/jb.181.19.6152-6159.1999;
RA Rava P.S., Somma L., Steinman H.M.;
RT "Identification of a regulator that controls stationary-phase expression of
RT catalase-peroxidase in Caulobacter crescentus.";
RL J. Bacteriol. 181:6152-6159(1999).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000305}.
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DR EMBL; CP001340; ACL94196.1; -; Genomic_DNA.
DR EMBL; AF170912; AAF01798.1; -; Genomic_DNA.
DR RefSeq; WP_010918581.1; NC_011916.1.
DR RefSeq; YP_002516104.1; NC_011916.1.
DR AlphaFoldDB; B8H173; -.
DR SMR; B8H173; -.
DR PRIDE; B8H173; -.
DR EnsemblBacteria; ACL94196; ACL94196; CCNA_00731.
DR GeneID; 7332818; -.
DR KEGG; ccs:CCNA_00731; -.
DR PATRIC; fig|565050.3.peg.721; -.
DR HOGENOM; CLU_004131_4_2_5; -.
DR OMA; AHERIMY; -.
DR OrthoDB; 764332at2; -.
DR PhylomeDB; B8H173; -.
DR Proteomes; UP000001364; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..637
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_0000378296"
SQ SEQUENCE 637 AA; 68498 MW; 77F9B28AB4B0F1B6 CRC64;
MPIRRLPPET VNRIAAGEVV ERPASAIKEL VDNAIDAGAT RIEVEAHGGG LTRILVADDG
CGLSPEELPV AIERHATSKL APDADGLWDL LRIHTMGFRG EALPSIGSVA RLQISSRAKG
AKDAFSILVE GGQVGEVAPA AFPGPHGARI EVRDLFYATP ARLKFMKSER AEALAITEEI
KRQAMANESV GFSLDIDGRR VLRLPPEHPG PQGRLARLAA VLGREFQENA LEIDQTRDGV
RLSGFAGLPT YNRGNAAHQY LFVNGRPVRD RLLQGALRAA YADFLARDRH PTAALYVTLE
TTEVDVNVHP AKAEVRFRDP ALVRGLIVGA LRHALAGAGH RASTTVAAQA LDSIRAQQSP
FPGYQPQYQP GPSPAGFSAW REGGWTPPTQ RPMDLPGLNE VSARVEPSYG GDLAGVVREA
YAAAAFEDRP PTDYPGATAP FDPVDYPLGA ARAQVHETYI VAQTRDGMVI VDQHAAHERL
VYERMKGEMA SGGVTRQTLL LPEVVDLDPA EAERVVARAE ELAGLGLVLE SFGPGAVLVR
ETPALLGKTD AAALVRDIAD DLAENGQALA LKERLEEVCS TMACHGSVRA GRRLNGAEMN
ALLREMEATP HSGQCNHGRP TYVELKLADI EKLFGRR