MUTL_CELJU
ID MUTL_CELJU Reviewed; 626 AA.
AC B3PDC3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CJA_3081;
OS Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp.
OS cellulosa).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Cellvibrionales;
OC Cellvibrionaceae; Cellvibrio.
OX NCBI_TaxID=498211;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ueda107;
RX PubMed=18556790; DOI=10.1128/jb.01701-07;
RA DeBoy R.T., Mongodin E.F., Fouts D.E., Tailford L.E., Khouri H.,
RA Emerson J.B., Mohamoud Y., Watkins K., Henrissat B., Gilbert H.J.,
RA Nelson K.E.;
RT "Insights into plant cell wall degradation from the genome sequence of the
RT soil bacterium Cellvibrio japonicus.";
RL J. Bacteriol. 190:5455-5463(2008).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000934; ACE83766.1; -; Genomic_DNA.
DR AlphaFoldDB; B3PDC3; -.
DR SMR; B3PDC3; -.
DR STRING; 498211.CJA_3081; -.
DR EnsemblBacteria; ACE83766; ACE83766; CJA_3081.
DR KEGG; cja:CJA_3081; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_2_6; -.
DR OMA; AHERIMY; -.
DR Proteomes; UP000001036; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..626
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000096633"
SQ SEQUENCE 626 AA; 69546 MW; C8FDAD3F5B3ED65B CRC64;
MIPMRKIKLL SPRLANQIAA GEVVERPSSV IKELLENSLD AGATRLDIEI EDGGIKLMRV
RDNGGGIDKD DLPLALSRHA TSKIYELDDL EAVATLGFRG EALASISSVA RLALVSSTSE
DSAGWQVVAE GRDMETQISP APHPRGTTVE VRDLFFNTPA RRKFLRSEKT EYTHLEDVVK
RLALSRFDVA FNLRHNGRAI YAWRAGDSQL EQERRVAQVC GPAFMENAVF IEMERGSLRL
WGWVAQPTFS RSQADLQHFY VNGRAIRDKL VSHAVRQAYQ DVLYHGRHPA FVLYLELDPS
TVDVNVHPTK HEVRFRDNRT VHDFIYSSLH HALAKVRPED TLARKAADLG EDTPGIAPYA
VSPRPLVEGI AAGEFKGQGA MSFAPSTSGG YRPGYTSVSP GTIREQMHTY GELLASAEPV
TARALPQTPT EDIPPLGYAL AQLKGIYILA ENAQGLIVVD MHAAHERITY ERMKAAYAHG
GLQTQPLLVP ESIAVSEKEA DCAEQFADIF KTLGFELQRA GPETLLIRQL PVILNRAQAE
QLVRDVLSDL IEHGTSERIQ HHINEILATM ACHGSVRANR KLTIPEMNAL LRDMEATERS
GQCNHGRPTW FLQSLDELDK LFMRGQ