ID   MUTL_CHLAB              Reviewed;         582 AA.
AC   Q5L4T7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CAB920;
OS   Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=218497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27085 / S26/3;
RX   PubMed=15837807; DOI=10.1101/gr.3684805;
RA   Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D.,
RA   Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D.,
RA   Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A.,
RA   Price C., Barrell B.G., Parkhill J., Longbottom D.;
RT   "The Chlamydophila abortus genome sequence reveals an array of variable
RT   proteins that contribute to interspecies variation.";
RL   Genome Res. 15:629-640(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR848038; CAH64359.1; -; Genomic_DNA.
DR   RefSeq; WP_011097425.1; NC_004552.2.
DR   AlphaFoldDB; Q5L4T7; -.
DR   SMR; Q5L4T7; -.
DR   PRIDE; Q5L4T7; -.
DR   EnsemblBacteria; CAH64359; CAH64359; CAB920.
DR   KEGG; cab:CAB920; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_0; -.
DR   OMA; QHRAHER; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001012; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..582
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096634"
SQ   SEQUENCE   582 AA;  65293 MW;  1FA23EC69C4B301B CRC64;
     MAVRPRIQLL DTVTINQIAA GEVIENAVSV VKELVENALD AGADEIEVET LGGGQGLIVV
     KDNGCGMSSD EVTLALKRHA TSKIEEFSDV FSLSSFGFRG EALPAIASIS KMEILSCPKG
     EEGSRTIIHG GEVIAAEAKP RQLGTTISVD SLFYNVPVRR GFQKSPQTNR IAMRKLLENR
     ILSLESVGWS WISERQQEFH ILKHQGLAER VAFVMGEGFM QEALRVDRVE EPIRIVGFLG
     SPCFHRPTRL GQRIFINDRP VDSPLISKQI SEAYTMLLPP QRYPVFVLKL YLPPQWCDFN
     VHPQKTEVRI LKEEFVREFL SESIGEVLAR SQESSSYKKT SLTLPTLRFF DGQLPEISLE
     QPRESMSLPV TQLATPSIRS ISSLGCQQEI PAVDTQTEIV WGESQEVRFL TSLGKIVLAE
     DSEGVHAIFT EAARKHLFYL SLIENQQEHY KSQSFLVPLC LEVTPQERVF LLSHIEEFKQ
     LGIEISQIGP CVFAIESAPT FIGEEELKSW ILSLAAESHT KVDKKAIALL IKESLTQTIF
     GKTLRTFDIS WLSLLWQIGK PEKAFDGTLI RRLILDEDFI KE