ID   MUTL_CHLCH              Reviewed;         644 AA.
AC   Q3AUA2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Cag_0145;
OS   Chlorobium chlorochromatii (strain CaD3).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=340177;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CaD3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Chlorobium chlorochromatii CaD3.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000108; ABB27423.1; -; Genomic_DNA.
DR   RefSeq; WP_011361198.1; NC_007514.1.
DR   AlphaFoldDB; Q3AUA2; -.
DR   SMR; Q3AUA2; -.
DR   STRING; 340177.Cag_0145; -.
DR   EnsemblBacteria; ABB27423; ABB27423; Cag_0145.
DR   KEGG; cch:Cag_0145; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_0_10; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..644
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010001"
SQ   SEQUENCE   644 AA;  73251 MW;  39590781431CBF7E CRC64;
     MPIITRLPDS VANKISAGEV VQRPASVVKE LLENAIDAGA TKISVTIKDA GKELIRIADN
     GVGMNRDDAL LCVERFATSK IKSADDLDAL HTLGFRGEAL ASICSVSHFE LKTRQADATL
     GLLFRYDGGS LVEELEVQAE QGTSFSVRNL FYNVPARRKF LKSNATEYHH LFEIVKSFTL
     AYPEIEWRMV NDDEELFNFK NNDVLERLNF YYGDDFASSL IEVAEQNDYL PIHGYLGKPA
     LQKKRKLEQY FFINRRLVQN RMLLQAVQQA YGDLLVERQT PFVLLFLTID PSRIDVNVHP
     AKLEIRFDDE RQVRSMFYPV IKRAVQLHDF STNISVIEPF ASASEPFVGS SSQPIFSSTS
     SQAPRMGGGS RRFDLSDAPE RAITKNELYR NYREGAFSSP SVASYDAPSP LQQGGLFALA
     SAEESLFGAQ AVHEASENIE AFQLSPLDNI VEHKEVEPKI WQLHNKYLIC QIKTGLMIID
     QHVAHERVLY ERALEVMQQN VPNAQQLLFP QKVEFRAWEY EVFEEIRDDL YRLGFNVRLF
     GNRTVMIEGV PQDVKSGSEV TILQDMITQY QENATKLKLE RRDNLAKSYS CRNAIMTGQK
     LSMEEMRSLI DNLFATREPY TCPHGRPIII KLSLDQLDKM FGRK