ID   MUTL_CHLCV              Reviewed;         580 AA.
AC   Q821I9;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CCA_00951;
OS   Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)
OS   (Chlamydophila caviae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=227941;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-813 / DSM 19441 / 03DC25 / GPIC;
RX   PubMed=12682364; DOI=10.1093/nar/gkg321;
RA   Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T.,
RA   Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A.,
RA   Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O.,
RA   Salzberg S.L., Hsia R.-C., McClarty G., Rank R.G., Bavoil P.M.,
RA   Fraser C.M.;
RT   "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC):
RT   examining the role of niche-specific genes in the evolution of the
RT   Chlamydiaceae.";
RL   Nucleic Acids Res. 31:2134-2147(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE015925; AAP05690.1; -; Genomic_DNA.
DR   RefSeq; WP_011006903.1; NC_003361.3.
DR   AlphaFoldDB; Q821I9; -.
DR   SMR; Q821I9; -.
DR   STRING; 227941.CCA_00951; -.
DR   EnsemblBacteria; AAP05690; AAP05690; CCA_00951.
DR   KEGG; cca:CCA_00951; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_3_0; -.
DR   OMA; QHRAHER; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002193; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..580
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177935"
SQ   SEQUENCE   580 AA;  64687 MW;  6FF2E4EECCB1E3A3 CRC64;
     MSSRNPIQLL DTITINQIAA GEVIENSISV VKELVENALD AGADEIEVET LGGGQGLIVV
     KDNGCGMSSE DVALALKRHA TSKIGEFSDV FSLSSFGFRG EALPAIASIS KMEILSCPRA
     GEGSRTIIHG GEIVTSEAKP RQVGTTISID SLFYNVPVRR GFQKSPQTDR MAMRKLLENR
     ILSVENVGWS WVSERQQEFH IFKHQGFAER VAFVMGEGFM QEALRVDKGG NLVRVVGFLG
     SPGFHRPTRL GQRVFINDRP VDSTFISKKI SEAYSMLLPP QRYPVFVLKL YLPPEWCDFN
     VHPQKTEVRI LREEFVGEFL SETIGEVLAR PQEVSVFETA STLPALRFFD EQLPESALEG
     LQGSNVLPVV KLTPSSSGSL PFLDREPDPL PVDRQTQISW GASQEVRFLT SLGKIVLAED
     SEGVHAIFTE SARKHLFYLS LVENHQHNYK SQSFLVPLCL EVTPQERIFL SSHIEEFKLL
     GIEISQMGPC VFSIESAPTF IGEEELKLWI LSLAAESAKV DKRAMTLLIK EALTQTIFCK
     TLRAFDISWL SLLWQLGKPE KAFDGSQIRR LVLDEDFIKE