ID   MUTL_CHLFF              Reviewed;         580 AA.
AC   Q256F3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CF0063;
OS   Chlamydia felis (strain Fe/C-56) (Chlamydophila felis).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=264202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fe/C-56;
RX   PubMed=16766509; DOI=10.1093/dnares/dsi027;
RA   Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H.,
RA   Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H.,
RA   Hattori M., Kuhara S., Shirai M.;
RT   "Genome sequence of the cat pathogen, Chlamydophila felis.";
RL   DNA Res. 13:15-23(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AP006861; BAE80835.1; -; Genomic_DNA.
DR   RefSeq; WP_011457620.1; NC_007899.1.
DR   AlphaFoldDB; Q256F3; -.
DR   SMR; Q256F3; -.
DR   STRING; 264202.CF0063; -.
DR   KEGG; cfe:CF0063; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_3_0; -.
DR   OMA; QHRAHER; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001260; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..580
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096635"
SQ   SEQUENCE   580 AA;  64797 MW;  FC9898E7BC1E01A1 CRC64;
     MPSRPLIQLL DTTTINQIAA GEVIENSISV VKELVENALD AGADEIEVET LGGGQGLIVV
     KDNGCGMSAE DVTLALKRHA TSKIGEFSDI FSLSSFGFRG EALPAIASIS KMEILSCPRI
     GEGSRTIIHG GEIIASEAKP RQLGTTISID SLFYNVPVRR GFQKSPQADR IAMRKLLENR
     ILSIEGVGWS WVSERQQEFH ILKHRGFAER VGFVMGEGFM QEALRVDSGE RPVCVRGFLG
     SPGFHRPTRS GQRVFINDRP VDSVFISKQI REAYSMLLPP QRHPVFVLKL YLPPEWCDFN
     VHPQKTEVRI LKEEFVGEFL SESIGEVLAR PQESSVSEKT IFSLPALRFF DEHLAERSSV
     EPLESISLPE LSIPPKVPLP FLDKGQDIPT TDGQMQIDWG VSQEVRFLTS LGKIVLAEDS
     EGVHAIFTEA ARKHLFYLAL TENQQYNYKS QSFLVPLCLE VTPQEGIFLS SHVEDFKQLG
     IELSQMGPCI FAIDSAPTFI GEEELKSWIL FLAAESHAKV DRKAVALLIK ETLTQTVFCK
     TLRPFDISWL SLLWQIGKPE KAFDGTQIRR LVLDEDFIKE