ID   MUTL_CHLL2              Reviewed;         629 AA.
AC   B3EHI9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Clim_2328;
OS   Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=290315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 245 / NBRC 103803 / 6330;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Ovchinnikova G., Zhao F., Li T., Liu Z.,
RA   Overmann J., Bryant D.A., Richardson P.;
RT   "Complete sequence of Chlorobium limicola DSM 245.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001097; ACD91351.1; -; Genomic_DNA.
DR   RefSeq; WP_012467216.1; NC_010803.1.
DR   AlphaFoldDB; B3EHI9; -.
DR   SMR; B3EHI9; -.
DR   STRING; 290315.Clim_2328; -.
DR   EnsemblBacteria; ACD91351; ACD91351; Clim_2328.
DR   KEGG; cli:Clim_2328; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_0_10; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000008841; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..629
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096636"
SQ   SEQUENCE   629 AA;  72052 MW;  9D880B5B86694940 CRC64;
     MAKISRLPDT VANKISAGEV VQRPASVVKE LLENAIDAGA SRITVMIKDA GKELIRIIDN
     GTGMNREDAL LCVERFATSK ISVVDDLDTL MSLGFRGEAL ASISSVSHFE LKTRQAFSPL
     ALKFRYEGGA LAEESEVSGE EGTSISVRNL FYNVPARRKF LKSNATEFRH IFESVRSLSL
     AYADIEWRMY NDDEELFHFR NPDIRERLNY YYGSDFSEGL ISITEENDYL SIHGFIGKPG
     MLKRHKADQL FYINRRIIQN RMLSQALQQA YGELLEDRQA PFAMLFLGID PSRVDVNVHP
     AKLEVKFEDE RSVRNMFYPV VKRAVQLHDF SPDASFVPDQ GVQGESIQPE DEALNRRLMY
     HERPGRMATT AELYTDYRQH SLPQSSGKEH GPQSRQGEFF SAHEPLERWK KEGVEPEGDE
     VFTTMLQSRF HDDESAAGGG TEPKIWQLHN KYIICQIKNG MMIIDQHVAH ERVLYERALD
     VMNQNVPNSQ QLLFPQKIEM RQWEYEVFEE IRDDLYRLGF NLRDFGSKTV MIEGIPQDVR
     SGTEVTILQD MIAGYQENAS KLKLEKRDNL AKSYSCRNAI MAGQKLSLEE MRSLIDNLFA
     TRVPYSCPHG RPVIIKLMLD QLDRMFGRT