ID   MUTL_CHLL3              Reviewed;         626 AA.
AC   Q3B1F8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Plut_1981;
OS   Chlorobium luteolum (strain DSM 273 / BCRC 81028 / 2530) (Pelodictyon
OS   luteolum).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Pelodictyon.
OX   NCBI_TaxID=319225;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 273 / BCRC 81028 / 2530;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Pelodictyon luteolum DSM 273.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000096; ABB24823.1; -; Genomic_DNA.
DR   RefSeq; WP_011358693.1; NC_007512.1.
DR   AlphaFoldDB; Q3B1F8; -.
DR   SMR; Q3B1F8; -.
DR   STRING; 319225.Plut_1981; -.
DR   EnsemblBacteria; ABB24823; ABB24823; Plut_1981.
DR   KEGG; plt:Plut_1981; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_0_10; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002709; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..626
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010054"
SQ   SEQUENCE   626 AA;  70697 MW;  EA867807CDF17D5C CRC64;
     MPSIARLPDN VANKISAGEV VQRPASVVKE LLENAIDSGA DRISVVIKDA GRELVRIIDN
     GRGMSRADAL LSVERFATSK LRDVDDLDTL GTLGFRGEAL ASISSVSHFE LRTRMTDAPV
     ALRFRYEGGI AVEESEVQGE AGTSVSVRNL FYNVPARRKF LKSNATEYGH IFELVRSFSL
     AYPEIQWQLL NDDQELFNFR TSDMLERLDT FYGKGFADSL IEVGEENDYL SIRGYIGRPA
     LQKRKKLDQY FFINRRPIQN RMLTQALQQA YAELLVERQA PFALLFLGID PSRVDVNVHP
     AKLEVRFDDE RSVRNMFYPV IKRAVTLHDF SPDLAAGGRT SQAGDDSASR GFTHAGGGGF
     RTLAFQEVPE RAITTGELYG SYREGAFGSS RPAVPQPSHQ EVMFPVPEVP AAREDISQLL
     RSSMHEGPEG AGVEPKGEEP KIWQLHNKYL ICQIKTGLMI IDQHVAHERV LYERAVEVME
     SRVPNSQQLL FPQKVEFRPW EYEVFEEIKD DLYRLGFNLR SFGTRAVMIE GVPQDVRPGS
     EATIMQDMIA EYRENATRLR LERRDNLAKS YSCRNAIMAG QKLSMGEMRT LIDNLFATRE
     PYSCPHGRPV IIKMTLTELD HMFGRS