ID   MUTL_CHLMU              Reviewed;         576 AA.
AC   Q9PJG5;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL; OrderedLocusNames=TC_0864;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; AE002160; AAF39660.1; -; Genomic_DNA.
DR   PIR; G81657; G81657.
DR   RefSeq; WP_010231782.1; NZ_CP027217.1.
DR   AlphaFoldDB; Q9PJG5; -.
DR   SMR; Q9PJG5; -.
DR   STRING; 243161.TC_0864; -.
DR   EnsemblBacteria; AAF39660; AAF39660; TC_0864.
DR   GeneID; 1246232; -.
DR   KEGG; cmu:TC_0864; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_3_0; -.
DR   OMA; QHRAHER; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000800; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..576
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177936"
SQ   SEQUENCE   576 AA;  64145 MW;  E338E8BDFBAC8E7F CRC64;
     MSLSSSRIRL LDSATVNQIA AGEVIENAAS VVKELIENAL DAGADEISIE TLGGGKGQIV
     VRDNGIGMDA DEVAVAIQRH ATSKISHFAD IFSLASFGFR GEALPAIASI SKMEIHTAKV
     NGLGSKTLIE KGEPVCCEAC PRQPGTTISV NSLFYNVPMR QSFQKSPQMD RLAIRRLLEN
     SILSTEGIKW TWISERRQEL NIAKNQGFTE RVALVMGEAF VNEAFLIDKR QNELHLTGFL
     GSPSMHRSTR QGQRLFINNR AVESSFISRK VAEAYAWMLP AQRYPAFVLK LSVPPMWCDF
     NVHPQKTEVR LLQEGQIGAL LVEAISEVLL HRSPSLEEKM VEPTMESPLI ENGGLEIPSI
     RPVAISTPLS CPNFLQQSFV ETEANRALCK EQENLALPII ERVRFLASLG KVILVEDSEG
     VHALFVQAAR KHLFYISLLS KRSDSLLACQ MFLVPPTVQM TKLEADFLQT RLESLAAQGI
     ELCRISPDSF AIESAPPFIQ EEELKEWIIS LAHEGAFQVN ESFEQLVENT VQKLAFSKNT
     RAFDHSWINV LWQIGKPEKA FDGETIRRLV LEEDFM