ID   MUTL_CHLPD              Reviewed;         624 AA.
AC   A1BCW2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=Cpha266_0172;
OS   Chlorobium phaeobacteroides (strain DSM 266).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=290317;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 266;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T.,
RA   Overmann J., Bryant D.A., Richardson P.;
RT   "Complete sequence of Chlorobium phaeobacteroides DSM 266.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000492; ABL64239.1; -; Genomic_DNA.
DR   RefSeq; WP_011744079.1; NC_008639.1.
DR   AlphaFoldDB; A1BCW2; -.
DR   SMR; A1BCW2; -.
DR   STRING; 290317.Cpha266_0172; -.
DR   EnsemblBacteria; ABL64239; ABL64239; Cpha266_0172.
DR   KEGG; cph:Cpha266_0172; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_10; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000008701; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..624
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010002"
SQ   SEQUENCE   624 AA;  70993 MW;  294CD3E39D5F146F CRC64;
     MAKIARLPDN VANKISAGEV VQRPASVIKE LLENAIDACA SKITVTIKDA GKELVQIVDN
     GIGMSRQDAL LSVERFATSK ISGVEDLDSL MSLGFRGEAL PSIASVSQFE LKTKPEGALL
     GFRFRCDGGE PVEESEVNAE KGTTITVRNL FYNVPARRKF LKSNATEFRH IFESVKSLAL
     AYPEIEWKMV SDDEELFHFR TPDIYERLDA FYGENFSLSL IPVSEENDYL SISGFLGKPG
     MQKRQKLDQY IYVNRRIIQN RMLSQALQQA YGELLVERQA PFALLFLGID PSRIDVNVHP
     AKLEVKFEDE RSVRTMFYPV IKRTIQLHDF SPDAAEKEPC SIKEGTLDCS SRKLGFQDIA
     EPASTTSTLY ANYRQGAFGD TPFERPAYAE KEPRPSSINT GFERFEPDLR EGGDLFSTTL
     QARPYEDDNT PDPGENDPKI WQLHNKYIIC QIKTGMMIID QHVAHERVLY ERAVDVMNQN
     VPNSQQLLFP QKIELRAWEY EVFEEIRDDL YRLGFNLRSF GAKTVMIEGI PQDVRPGTEV
     TILQDMITEF QENSSKLKLE RRENLARSYS CRNAIMAGQK LSLEEMRSLI DNLFATRVPY
     TCPHGRPVII KLSLDQLDRM FGRK