ID   MUTL_CHLPM              Reviewed;         614 AA.
AC   A4SGM5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Cvib_1624;
OS   Chlorobium phaeovibrioides (strain DSM 265 / 1930) (Prosthecochloris
OS   vibrioformis (strain DSM 265)).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=290318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 265 / 1930;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Mikhailova N., Li T., Overmann J.,
RA   Schuster S.C., Bryant D.A., Richardson P.;
RT   "Complete sequence of Prosthecochloris vibrioformis DSM 265.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000607; ABP37634.1; -; Genomic_DNA.
DR   RefSeq; WP_011890857.1; NC_009337.1.
DR   AlphaFoldDB; A4SGM5; -.
DR   SMR; A4SGM5; -.
DR   STRING; 290318.Cvib_1624; -.
DR   EnsemblBacteria; ABP37634; ABP37634; Cvib_1624.
DR   KEGG; pvi:Cvib_1624; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_10; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..614
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000076704"
SQ   SEQUENCE   614 AA;  69232 MW;  2AED2FC2058673EC CRC64;
     MAGIARLPES VANKISAGEV VQRPVSVVKE LLENAIDAGA DRISVIISDA GKELVRIVDN
     GCGMERDDAL LSVERFATSK IRGVEDLEDL SSLGFRGEAL ASISSVSHFE LRTAVEGSPL
     ALSFRYEGGV LVEEARVQGE RGTSISVRNL FYNVPARRKF LKSNATEYGH IYELVRSFVL
     ACPEISWQMV NDGEELFNFR TPDLNERLDF FYGSGFAESL VPVTEENDYI SIRGFIGRPA
     LQKRRRLDQY FFINRRLVQN RMLSQALQQA YGELLVERQA PFALLFFEMD PSRIDVNVHP
     AKLEVRFEDE RSVRNMFYPV IKRAVRSYDF SPDLASGELP PLSTRYPSPS PIAFQDVAEP
     AVTKGELYRN YREGAFSTSR PQDNLPEGFQ EQLFSPPEPP AGFVGTASLA GSGGNEDEVP
     LGDAVAEVKI WQLHNKYLIC QIKTGLMIID QHVAHERVLY ERAVDVMETS VPNSQQLLFP
     QKVELRPWDW EIFEEIRDDL YRLGFNLSLF GSRTVMIEGV PQDVRPGSEV SILQDMIAEY
     SENASKLKLE KRDNLAKSYS CRNAIMTGQK LSLQEMRSLI DSLFATRDPY CCPHGRPVII
     KMTLGQLDHM FGRK