MUTL_CHLPN
ID MUTL_CHLPN Reviewed; 580 AA.
AC Q9Z794; Q9JQ29;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=DNA mismatch repair protein MutL;
GN Name=mutL; OrderedLocusNames=CPn_0812, CP_1059, CpB0841;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000305}.
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DR EMBL; AE001363; AAD18950.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38832.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA99020.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98770.1; -; Genomic_DNA.
DR PIR; A72032; A72032.
DR PIR; B86592; B86592.
DR RefSeq; NP_225007.1; NC_000922.1.
DR RefSeq; WP_010883449.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z794; -.
DR SMR; Q9Z794; -.
DR STRING; 115711.CP_1059; -.
DR PRIDE; Q9Z794; -.
DR EnsemblBacteria; AAD18950; AAD18950; CPn_0812.
DR EnsemblBacteria; AAF38832; AAF38832; CP_1059.
DR GeneID; 45050867; -.
DR KEGG; cpa:CP_1059; -.
DR KEGG; cpj:mutL; -.
DR KEGG; cpn:CPn_0812; -.
DR KEGG; cpt:CpB0841; -.
DR PATRIC; fig|115713.3.peg.891; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_3_0; -.
DR OrthoDB; 764332at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..580
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_0000177937"
SQ SEQUENCE 580 AA; 65001 MW; D8AA7DD12F957F32 CRC64;
MSTRRPIQLL DPLTINQIAA GEVIENSVSV VKELIENSLD AGADEIEIET LGGGQGAIII
RDNGCGFRAE DIPIALQRHA TSKIREFSDI FSLNSFGFRG EALPSIASIS KMEIQSSIEG
DEGVRTVIHG GDIVSCEPCA RQLGTTVIVN SLFYNVPVRR GFQKSMQSDR LGIRKLIENR
ILSTANIGWS WISEGHHEIQ IAKQQGFQER VAYVMGDHFM QDALTIDKEA NGVRIVGVLG
SPSFHRPTRQ GQKIFINDRP IESLFISKKV GDAYALLLPL HRYPVFVLKL YLPSSWCDFN
VHPQKIEARI LKEELVGDCI KEAIVETLAC PPGILCRTHQ EIEESDSVPL PMFRMLETSD
VQEEESVEFD QNLFAYSSED VSLEKQEYTS RGPKSQMDWI YSSDVRFLTS LGRVVLAEDL
EGVHIIFTAA ARKHLFFLSL MQENSRMYQS QALLIPLRLQ VTPEEAFFFS HHGRTLCDLG
IEISQVGPCV FSIESTPTVI GEEELKEWLL LLAARGSTDI NSEALTALMK ETLTQATFSK
HQHVFDVSWL KLLWSVGKPE KGFDGARIRR LILDSDFMEG
