ID   MUTL_CHLT3              Reviewed;         640 AA.
AC   B3QW86;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Ctha_0730;
OS   Chloroherpeton thalassium (strain ATCC 35110 / GB-78).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chloroherpeton.
OX   NCBI_TaxID=517418;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35110 / GB-78;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Liu Z., Li T., Zhao F., Overmann J.,
RA   Bryant D.A., Richardson P.;
RT   "Complete sequence of Chloroherpeton thalassium ATCC 35110.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001100; ACF13199.1; -; Genomic_DNA.
DR   RefSeq; WP_012499283.1; NC_011026.1.
DR   AlphaFoldDB; B3QW86; -.
DR   SMR; B3QW86; -.
DR   STRING; 517418.Ctha_0730; -.
DR   EnsemblBacteria; ACF13199; ACF13199; Ctha_0730.
DR   KEGG; cts:Ctha_0730; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_0_10; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000001208; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..640
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096640"
FT   REGION          332..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   640 AA;  73296 MW;  45107DF83CD8B09E CRC64;
     MSLIKKLPDI VANKISAGEV VQRPASAVKE LLENAIDAGA DEITLAIKAA GKTLIQVIDN
     GCGLSEEDAT LCFERFATSK ISDVGDLENL HTLGFRGEAL ASIASVSQVE LKTKRYDDRT
     GTLVKISGGR FEEVSRTETP NGTAFSIRNL FYNVPARRKF LKTNATEYKH IFETVQAQTL
     VYPDIKWRFY SDDEEIFSFL NNNLSERLDY FFGKDFSQNL IEFTEENDFM KLRGYLGKPA
     MMKRTKNQQF LFINNRVTQS KLLSSAIMTA YGELLGEREY PFFLIYMDIA PHYIDVNVHP
     TKMEVKFDDE RNIYNMVHSV VKHRIKTLDF SPNVQVEEKP DSPRPTGESF NFPGVAKRLS
     YNDRDADMRS SNALFRDYKT YYKAQDERAE PGFFANPKRE MDWRSSLPAH TEASLTPPKQ
     AEPEGNPTFH DGSRQMEIFI QSRDDEPATA GQERFVWQLH NTYILTQIKS GLLIIDQHVA
     HERILYERAI AVMESNVPNS QQLLFPHSAK LSAWEFDVLK EIKTDLVQLG FSLRILDQRT
     VLVEGIPPDV MPGREERILH EMLEQYQDYQ QNLKLEQRDN VAKSYACRSS IMAGQKLSRN
     EMTSLIDQLF ATSMPYVCPH GRPIIIKLSI EELDKMFGRS