ID   MUTL_CHLTB              Reviewed;         576 AA.
AC   B0BA28;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=CTLon_0832;
OS   Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=471473;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCH-1/proctitis;
RX   PubMed=18032721; DOI=10.1101/gr.7020108;
RA   Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA   Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA   Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT   "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT   venereum isolates.";
RL   Genome Res. 18:161-171(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AM884177; CAP07229.1; -; Genomic_DNA.
DR   RefSeq; WP_009873910.1; NC_010280.2.
DR   AlphaFoldDB; B0BA28; -.
DR   SMR; B0BA28; -.
DR   KEGG; ctl:CTLon_0832; -.
DR   HOGENOM; CLU_004131_4_3_0; -.
DR   OMA; QHRAHER; -.
DR   Proteomes; UP000000794; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..576
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096641"
SQ   SEQUENCE   576 AA;  64178 MW;  D0437D48620A919F CRC64;
     MSLSPSRIRL LDSVTVNQIS AGEVIENAAS VVKELIENSL DAGADEIHIE TLGGGRGQIV
     VRDNGVGMDP EEVPVALQRH ATSKIAHFAD IFSLASYGFR GEALPSIASI SKMEIHTARA
     GGLGSKTLIE KGEPVCCEPA PRQQGTTIAV HSLFYNVPMR QSFQKSPQMD RLAIRRLLEN
     SVLSSEGIGW TWISERRQEL HVAKKQGFIE RVALVLGESF VQEAFFIDKQ QGDLRVLGFL
     GSPNQHRSTR QGQRLFINNR AVESSFISKK VAEAYAWMIP AQRYPIFVLK LFLPPMWCDF
     NVHPQKTEVR LLQEGQISNL LVEAISEALL RRSSSLEEIV LKVPTEKIPI ENEGISVPSI
     RPAIVSAPLS CPTFSQQPYL KTEMATIVSR DSASSSLSVV EKVRFLTSLG KVLLVEDSEG
     VHVVFVQAAR KHLFYVSLLS ERLESRLACQ TFLLPPSVQM TKLEADFLQM RLEALTALGI
     ELSRISPDSF AIESAPPFIQ EEELKEWIVA LAQEGALHVG ESFEQLVENT VQKLVFSRNA
     RAFDYAWLDI LWKLGKPEKA FDGEMIRRLV LDDDFM