ID   MUTL_CHLTR              Reviewed;         576 AA.
AC   O84579;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL; OrderedLocusNames=CT_575;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; AE001273; AAC68177.1; -; Genomic_DNA.
DR   PIR; A71497; A71497.
DR   RefSeq; NP_220090.1; NC_000117.1.
DR   RefSeq; WP_009871940.1; NC_000117.1.
DR   AlphaFoldDB; O84579; -.
DR   SMR; O84579; -.
DR   STRING; 813.O172_03155; -.
DR   EnsemblBacteria; AAC68177; AAC68177; CT_575.
DR   GeneID; 884352; -.
DR   KEGG; ctr:CT_575; -.
DR   PATRIC; fig|272561.5.peg.627; -.
DR   HOGENOM; CLU_004131_4_3_0; -.
DR   InParanoid; O84579; -.
DR   OMA; QHRAHER; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..576
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177939"
SQ   SEQUENCE   576 AA;  64139 MW;  8AAF6CC19783F84E CRC64;
     MSLSPSRIRL LDSVTVNQIS AGEVIENAAS VVKELIENSL DAGADEIHIE TLGGGRGQIV
     VRDNGVGMDP EEVPVALQRH ATSKIAHFAD IFSLASYGFR GEALPSIASI SKMEIHTARA
     GGLGSKTLIE KGEPVCCEPA PRQQGTTIAV HSLFYNVPMR QSFQKSPQMD RLAIRRLLEN
     SVLSSEGIGW TWISECRQEL YVAKKQGFIE RVALVLGESF VQEAFFIDKQ QGDLRVLGFL
     GSPNQHRSTR QGQRLFINNR AVESSFISKK VAEAYAWMIP AQRYPIFVLK LFLPPMWCDF
     NVHPQKTEVR LLQEGQISNL LVEAISEALL RRSPSLEETV LKVPTEKIPI ENEGISVPSI
     RPAIVSAPLS CPTFSQQPYL KTEMATIVSR DSASSSLSVV EKVRFLTSLG KVLLVEDSEG
     VHVVFVQAAR KHLFYVSLLS ERLESRLACQ TFLLPSSVQM TKLEADFLQM RLEALTALGI
     ELSRISPDSF AIESAPPFIQ EEELKEWIVA LAQEGALHVG ESFEQLVENT VQKLVFSRNA
     RAFDYAWLDI LWKLGKPEKA FDGEMIRRLV LDDDFM